PMID: 6972434Feb 1, 1981Paper

Polyclonal activation of human peripheral blood B lymphocytes by formaldehyde-fixed Salmonella paratyphi B. I. Immunoglobulin production without DNA synthesis

The Journal of Experimental Medicine
W Y ChenG Virella

Abstract

A "new" polyclonal activator of human peripheral blood B cells, formaldehyde-fixed Salmonella paratyphi B, is described. This bacterium does not stimulate cell proliferation as measured by incorporation of tritiated thymidine but does stimulate a subpopulation of B cells to secrete large amounts of IgM, IgG, and IgA in 7-day cell cultures. The immunoglobulins (Ig) produced by cells responding to S. paratyphi B are not specific antibodies against the bacterial antigens. In comparison with other B cell activators (pokeweed mitogen, Staphylococcus aureus Cowan I, and lipopolysaccharide), S. paratyphi B stimulation produced greater amounts of IgM but less IgG than pokeweed mitogen (PWM) or S. aureus Cowan I; lipopolysaccharide failed to stimulate significant Ig production on day 7 in most cases. In addition, the response to S. paratyphi apparently did not require T cell collaboration. These results suggest that the B cell subpopulation(s) responding to S. paratyphi B may be more differentiated B cells than those responding to either PWM or S. aureus Cowan I. Peripheral blood mononuclear cells from five patients with common variable immunodeficiency without evidence of abnormal suppressor T cells or monocytes failed to respond to S....Continue Reading

References

Jan 1, 1978·European Journal of Immunology·O Ringdén, Rynnel-Dagöö
Jul 27, 1978·The New England Journal of Medicine·F P SiegalR A Good
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A S Fauci, K R Pratt
Jan 1, 1975·Transplantation Reviews·G Janossy, M Greaves
Jan 1, 1975·Transplantation Reviews·E Gronowicz, A Coutinho
Jul 1, 1974·The Journal of Experimental Medicine·M GreavesM Doenhoff

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Citations

Sep 1, 1981·The Journal of Experimental Medicine·A G BirdK Nilsson
Sep 1, 1989·Clinical Immunology and Immunopathology·F StüberW L Gross
Oct 1, 1986·European Journal of Clinical Investigation·W L GrossU Ullmann
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·L RäsänenH Arvilommi

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