PMID: 2029330Jan 1, 1991

Polyclonal activation of IgM antibodies to phospholipids in patients with idiopathic fetal growth retardation

American Journal of Reproductive Immunology : AJRI
T Kajino

Abstract

Phospholipid fractions and antibodies to phospholipids in the sera of normal pregnant women and patients with intra-uterine growth retardation (IUGR) were examined. Significant elevation of serum phospholipids were observed in the second and third trimesters of normal pregnancy. Serum concentration of phosphatidylserine and sphingomyelin was significantly lower in the third trimester in patients with IUGR than in normal pregnant women. Remarkable concentrations IgG and IgA antibodies to phospholipids were not observed in the patients or in normal pregnant women. Polyclonal activation of IgM antibodies was detected in normal pregnant women in the first and second trimesters but less so in the third. The activation of IgM antibodies was not observed in patients with IUGR induced by severe preeclampsia, but significant levels of IgM antibodies were detected in the third trimester in patients with idiopathic IUGR. It is suggested that antibody formation to phospholipids in normal pregnant women is induced by elevation of phospholipids and is down-regulated in the third trimester. Failure to down-regulate IgM antibodies may be related to the pathogenesis of idiopathic IUGR.

References

Feb 1, 1975·American Journal of Obstetrics and Gynecology·G AltshulerR Ermocilla
Sep 27, 1986·Lancet·C J LockwoodJ C Hobbins
May 1, 1986·The New England Journal of Medicine·R CariouJ Caen
Jan 1, 1987·Clinical Immunology and Immunopathology·D W BranchJ R Scott
Sep 1, 1987·Annals of Internal Medicine
Dec 1, 1988·Journal of Reproductive Immunology·T KajinoW D Billington
Nov 1, 1987·American Journal of Obstetrics and Gynecology·H C Wallenburg, N Rotmans
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·R A Scott
Jul 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·T KajinoJ A McIntyre
Jun 1, 1985·American Journal of Obstetrics and Gynecology·S W Walsh
Oct 1, 1985·American Journal of Obstetrics and Gynecology·W F Lubbe, G C Liggins
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Citations

Jun 1, 1992·Journal of Reproductive Immunology·J Y KwakA E Beer
Feb 10, 2018·Evolution, Medicine, and Public Health·Robert BayersdorfFrancesco Catania

Related Concepts

Autoantibodies
Fetal Growth Retardation
IgA2
Polyglobin
IgM2
Phospholipids

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