Polyclonal and compartmentalized infection by Mycobacterium tuberculosis in patients with both respiratory and extrarespiratory involvement

The Journal of Infectious Diseases
Darío García de ViedmaEmilio Bouza


Infection by Mycobacterium tuberculosis (MTB) is assumed to be caused by a single strain, and several MTB strains within the same patient are rarely considered. The present study analyzes the phenomenon of mixed infections by MTB in a group of 50 patients with both respiratory and extrarespiratory tuberculosis. First, the proportion of patients with infection by >1 strain was defined, and second, the clonal composition of the MTB populations at different infected sites was studied. In 3 (6%) of 50 patients, >1 strain was cultured, which indicates that mixed infections are not anecdotal. The coinfecting strains were not equally distributed at the respiratory and extrarespiratory site, which reflects a compartmentalization of the infection. In 1 patient, although 2 strains were found at the respiratory site, only 1 of these strains was involved in the extrarespiratory infection, which suggests that clonal selection can occur in the dissemination of the infection.


Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caroline AllixMaryse Fauville-Dufaux
Apr 29, 2006·The Pediatric Infectious Disease Journal·Darío García de ViedmaEmilio Bouza
Mar 31, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nicholas D WalterEdward D Chan
Dec 8, 2004·Journal of Clinical Microbiology·Isdore Chola ShamputaFrançoise Portaels
Aug 7, 2004·Journal of Clinical Microbiology·Darío García de ViedmaEmilio Bouza
Apr 7, 2006·Journal of Clinical Microbiology·Roxanne S AgaMidori Kato-Maeda
Jun 11, 2005·American Journal of Respiratory and Critical Care Medicine·Annelies van RieRobin M Warren
Aug 1, 2007·BMC Microbiology·Ana MartínDarío García de Viedma
Feb 26, 2014·Emerging Infectious Diseases·Christine BernardNicolas Veziris
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Pérez-LagoD García-de-Viedma
Apr 4, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adrian MuwongeTone B Johansen
Jun 16, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A MartínD García de Viedma
Mar 24, 2017·Pathogens and Disease·Amanda McIvorBavesh Davandra Kana
Apr 21, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M K N AndradeM H F Saad
Sep 3, 2008·European Journal of Pediatrics·Manal F El SayedUNKNOWN National Collaborative Perinatal Neonatal Network (NCPNN)
Feb 21, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Lisandra Serra DamascenoRosely Maria Zancopé-Oliveira
Jul 7, 2017·Scientific Reports·N F EgbeB M de C Bronsvoort
Jan 8, 2021·Frontiers in Genetics·Alexander Stephen ByrneKapil Tahlan
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