Polyclonal and monoclonal antibodies for treating acute rejection episodes in kidney transplant recipients

The Cochrane Database of Systematic Reviews
A WebsterJ C Craig

Abstract

Registry data shows that between 15-35% kidney recipients will undergo treatment for at least one episode of acute rejection within the first post transplant year. Treatment options include pulsed steroid therapy, the use of an antibody preparation, the alteration of background immunosuppression, or combinations of these options. In 2002, in the US, 61.4% patients with an acute rejection episode received steroids, 20.4% received an antibody preparation and 18.2% received both. To determine the benefits and harms of mono- or polyclonal antibodies (Ab) used to treat acute rejection in kidney transplant recipients. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (in The Cochrane Library, issue 2, 2005), MEDLINE (1966-June 2005), EMBASE (1980-June 2005), and the specialised register of the Cochrane Renal Group (June 2005). Randomised controlled trials (RCTs) in all languages comparing all mono- and polyclonal antibody preparations, given in combination with any other immunosuppressive agents, for the treatment of acute graft rejection, when compared to any other treatment for acute rejection. Two reviewers independently assessed trials for eligibility and quality, and extracted data. Results are expressed a...Continue Reading

Citations

Mar 10, 2011·Critical Care : the Official Journal of the Critical Care Forum·Emmanuel CanetElie Azoulay
May 7, 2008·Annales D'urologie·C LegendreE Thervet
Jul 22, 2017·The Cochrane Database of Systematic Reviews·Angela C WebsterSue J Carr
Jan 11, 2017·The Cochrane Database of Systematic Reviews·Penny HillAngela C Webster
Nov 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C KrislD J Taber
Jan 29, 2011·Néphrologie & thérapeutique·Eric ThervetChristophe Legendre

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