PMID: 7858972Jul 1, 1994

Polyclonal antibodies and catalysis

Bioorganic & Medicinal Chemistry
D B StephensB L Iverson


Some recent results involving catalytic polyclonal antibodies are described. Polyclonal antibodies isolated directly from serum contain the complete distribution of different IgG antibodies elicited via immunization, so catalytic results obtained with polyclonal antibodies can be used to characterize the overall catalytic activity produced in an animal in response to a given hapten. This new window on catalytic antibodies should be especially useful for identifying general trends relating hapten structure to antibody catalytic activity, for monitoring the maturation of catalytic activity during immunization, and for studying the variability of catalytic activity elicited in different animals immunized with the same hapten. Furthermore, studying the catalytic activity of polyclonal antibodies in serum may aid in the development of novel immunization-based therapies.


May 1, 1992·Science·A M ShusterA G Gabibov
Dec 19, 1986·Science·A TramontanoR A Lerner
Dec 19, 1986·Science·S J PollackP G Schultz

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