PMID: 6970323Jan 1, 1980Paper

Polyclonal antibody production in murine spleen cells induced by Staphylococcus

Microbiology and Immunology
M NakanoS Masuda

Abstract

Polyclonal plaque-forming cell (PFC) responses in murine spleen cells induced by Staphylococcus aureus and S. epidermidis were studied. Injection of Balb/c mice with S. aureus strain 248 beta H resulted in the generation of anti-trinitrophenyl (TNP) and anti-sheep red blood cell PFC in their spleens. Cultures of Balb/c mutant yielded many anti-TNP PFC. The larger the number of organisms that were added to the cultures, the better was the PFC response. Both living and killed organisms were capable of inducing the response, but an excess of living 248 beta H organisms in the cultures abrogated the response. All of the organisms (12 strains of S. aureus and 11 strains of S. epidermidis) freshly isolated from patients had the ability to induce the polyclonal PFC response in cell cultures. These organisms stimulated cultured C3H/HcJ mouse spleen cells, which were unresponsive to bacterial lipopolysaccharide (LPS). Cultured cells from the spleens of athymic mice also responded to these organisms, and the number of PFC in nu/nu cell cultures was always greater than in nu/+ cells prepared from a haired litter mate. Moreover, the responses of nu/nu spleen were lower than expected. These findings suggest that the polyclonal PFC response ...Continue Reading

References

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