PMID: 6973712Sep 1, 1981Paper

Polyclonal B-cell activity in myasthenia gravis

Neurology
A I LevinsonO Abramsky

Abstract

Using a protein A-reverse hemolytic plaque assay, we found that some patients with myasthenia gravis have increased numbers of circulating immunoglobulin secreting cells (IgSC). This pattern was not related to drug therapy, age, sex, duration of symptoms, thymectomy, or serum levels of AChR antibody, although elevated IgSC values tended to occur in patients with active symptoms. The responses of peripheral blood mononuclear cells to pokeweed mitogen were normal. These data suggest increased in vivo polyclonal B-cell activation in some myasthenic patients, although in vitro polyclonal B-cell activation is normal.

Citations

May 1, 1995·Annals of Neurology·R A LewisR P Lisak
Sep 7, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A I Qureshi, M F Suri
Mar 30, 2013·Autoimmunity Reviews·Sonia Berrih-AkninRobert P Lisak
Jan 12, 2012·Autoimmune Diseases·Samia Ragheb, Robert P Lisak
Dec 21, 2012·Annals of the New York Academy of Sciences·Robert P Lisak, Samia Ragheb
Oct 1, 1983·Clinical Immunology and Immunopathology·I Pardo, A I Levinson
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Jan 1, 2014·Journal of Autoimmunity·J S YiJ T Guptill
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Jan 1, 1985·Springer Seminars in Immunopathology·A I LevinsonM Kornstein

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