Polyclonal B lymphocyte activation induced by mouse hepatitis virus A59 infection

The Journal of General Virology
V LardansJ Coutelier

Abstract

Mouse hepatitis viruses (MHV) diversely affect immune responses, depending on the viral strain and the mouse genetic background. Here, we studied the effect of MHV-A59 infection on B cell responses of 129/Sv and CBA mice. Our results indicate that in these strains, MHV-A59 induces spleen cell activation that leads to enlargement of the spleen without structural alteration. Infection triggers production by B lymphocytes of large amounts of immunoglobulin G2a, mostly without viral specificity. This polyclonal immunoglobulin production is dependent on the presence of functional T helper cells. This polyclonal B lymphocyte activation induced by MHV-A59 infection can have pathological implications, such as the enhancement of concomitant autoimmune reactions.

Citations

Oct 24, 2002·Journal of Virological Methods·Patricia A MathieuLilia A Retegui
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jennifer D LarsonRoberta Pelanda
Aug 30, 2001·International Immunology·D Markine-GoriaynoffJ P Coutelier
Mar 5, 2009·International Immunopharmacology·José L AparicioLilia A Retegui
Jul 19, 2006·PLoS Pathogens·Wilson Savino
Sep 23, 2008·Developmental and Comparative Immunology·J E ButlerI Kacskovics
Feb 2, 2000·International Immunology·D Markine-GoriaynoffJ P Coutelier
Jul 7, 2007·Journal of Leukocyte Biology·Carolina L MontesAdriana Gruppi
Aug 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew GetahunJohn C Cambier
Feb 22, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Valéry Salle

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