Polyclonal gut colonization with extended-spectrum cephalosporin- and/or colistin-resistant Enterobacteriaceae: a normal status for hotel employees on the island of Zanzibar, Tanzania

The Journal of Antimicrobial Chemotherapy
Thomas BüdelAndrea Endimiani

Abstract

For low-income countries, data regarding the intestinal colonization with extended-spectrum cephalosporin-resistant (ESC-R) and colistin-resistant (CST-R) Enterobacteriaceae in the community are still scarce. Here, we investigated this phenomenon by analysing hotel employees in Zanzibar. During June to July 2018, rectal swabs from 59 volunteers were screened implementing selective enrichments and agar plates. Species identification was achieved using MALDI-TOF MS. Strains were characterized using microdilution panels (MICs), microarray, PCRs for mcr-1/-8, repetitive extragenic palindromic-PCR (rep-PCR) and WGS. Colonization prevalence with ESC-R-, CST-R- and mcr-1-positive Enterobacteriaceae were 91.5%, 66.1% and 18.6%, respectively (average: 2.2 strains per volunteer). Overall, 55 ESC-R Escherichia coli (3 also CST-R), 33 ESC-R Klebsiella pneumoniae (1 also CST-R), 17 CST-R E. coli and 21 CST-R K. pneumoniae were collected. The following main resistance genes were found: ESC-R E. coli (blaCTX-M-15-like, 51.0%), ESC-R K. pneumoniae (blaCTX-M-9-like, 42.9%), CST-R E. coli (mcr-1, 55%) and CST-R K. pneumoniae (D150G substitution in PhoQ). ESBL-producing E. coli mainly belonged to ST361, ST636 and ST131, whereas all those that wer...Continue Reading

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Citations

Mar 18, 2020·Antimicrobial Agents and Chemotherapy·Andrea EndimianiAlessandra Carattoli
Mar 12, 2020·Frontiers in Microbiology·Miklos FuziAkos Toth
Dec 11, 2019·The Journal of Antimicrobial Chemotherapy·Andrea EndimianiBarbara Willi
Dec 12, 2020·The Journal of Antimicrobial Chemotherapy·Yihienew M BezabihAnna Roujeinikova
Feb 9, 2021·BioMed Research International·Madubuike Umunna AnyanwuVincent Shodeinde Shoyinka
Aug 12, 2021·Infection Ecology & Epidemiology·Madubuike Umunna AnyanwuVincent Shodeinde Shoyinka
Apr 6, 2021·Deutsches Ärzteblatt International·Robin KöckBirgit Walther
Sep 4, 2021·International Journal of Microbiology·Patrick Eberechi AkpakaPadman Jayaratne

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