Polyclonal increase in certain IgG subclasses in mice persistently infected with the 87V strain of scrapie

Journal of Comparative Pathology
S C Collis, R H Kimberlin

Abstract

Eight different combinations of seven strains of scrapie agent and the three known Sinc genotypes of mice were screened for changes in the concentration of IgG in serum. A single radial immunodiffusion assay was used to measure IgG throughout the incubation period which in different models ranged from an average of 125 days to longer than the maximum observation period of about 600 days. The only major changes occurred with the 87V strain of scrapie injected intracerebrally (i.c.) or intraperitoneally (i.p.) into mouse strains of the Sinc genotype p7p7. IgG concentration reached 1.5 to 2.0 times the control values in i.c. infected mice, which developed clinical disease after 270 to 320 days and also in i.p. infected mice, which did not develop the disease within the 600-day observation period. At very high IgG concentration, the increase was polyclonal; it involved the IgG 1 subclass more than the others and was accompanied by an increased rate of IgG clearance from serum. It is suggested that some scrapie infections of mice (and sheep) may upset the control of IgG production. The underlying mechanism may involve cell-pathogen interactions which are common to all scrapie infections, but only lead to gross changes in IgG in some...Continue Reading

References

Jul 1, 1979·Journal of Comparative Pathology·S C CollisG C Millson
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B H TohD Dahl
Jan 1, 1987·The Journal of General Virology·M E Bruce, A G Dickinson
Mar 1, 1987·Veterinary Microbiology·H Fraser, C F Farquhar
Jun 1, 1987·Microbial Pathogenesis·R H KimberlinC A Walker
Jan 1, 1985·Veterinary Immunology and Immunopathology·C J Elleman
Oct 31, 1987·The Veterinary Record·G A WellsR Bradley
Dec 1, 1985·The Journal of General Virology·M E Bruce
Feb 1, 1967·The Journal of Infectious Diseases·C M EklundW J Hadlow
May 2, 1970·Nature·H Fraser, A G Dickinson
Nov 1, 1982·Journal of Neuroimmunology·K C KasperS B Prusiner
Jun 1, 1981·Infection and Immunity·D T KingsburyD C Gajdusek
Nov 1, 1982·The Journal of Infectious Diseases·W J HadlowR E Race
Oct 1, 1982·Journal of Wildlife Diseases·E S Williams, S Young
Jan 1, 1980·Journal of Wildlife Diseases·E S Williams, S Young
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

❮ Previous
Next ❯

Citations

Jan 1, 1994·Archives of Virology·R I CarpP D Mehta
Jul 20, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P AucouturierT Wisniewski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.