Oct 21, 2009

Polycomb group protein complexes

Yi chuan = Hereditas
Ke-Xue Ma, Xing-Zi Xi

Abstract

The transcriptional repressors of the polycomb group (PcG) proteins regulate the targeted genes expression through chromatin modifications. They can be separated biochemically and functionally into two major core multiprotein complexes: PRC1 (Polycomb repressive complex 1) and PRC2 (Polycomb repressive complex 2). Studies revealed that PcG proteins were not only crucial for correct execution of developmental programs but also involved in the regulation of cell proliferation, differentiation, and tumorigenesis. This paper summarizes the components of PcG proteins complexes, its silencing mechanisms and biological functions, and discusses the study of PcG proteins in future.

  • References24
  • Citations2
  • References24
  • Citations2

Citations

Mentioned in this Paper

PRC1 gene
Complex (molecular entity)
Cell Proliferation Regulatory Process
Transcription, Genetic
Polycomb Repressive Complex 2
Cell Differentiation Process
Repressor Molecules
PRC1 Complex Location
Chromatin Remodeling Factor
Chromatin Location

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