PMID: 11310593Apr 20, 2001Paper

Polycyclic aromatic compounds as anticancer agents: structure-activity relationships of chrysene and pyrene derivatives

Bioorganic & Medicinal Chemistry
Bimal K Banik, Frederick F Becker

Abstract

A large number of diamides and diamines were synthesized using 6-amino chrysene and 1-amino pyrene as starting materials. A structure activity study with cis-platinum as internal control against animal and human tumor lines was carried out in vitro. This study indicated that the in vitro cytotoxicity toward these lines depends on the functionality present in the molecules. The diamino compounds were found to be more potent than the diamides, and these were equally active irrespective of the end heterocyclic group, whereas the activity of the diamides was strongly dependent on the terminal unit. In general, the diamides containing chrysene as the chromophore were more active than those with a pyrene ring. The size of the end heterocyclic ring, along with the nature of the spacer connecting the polycyclic ring to the heterocyclic ring, seemed to affect the biological activity in certain cell lines. Hemolysis experiments on a lead compound established that it had activities similar to those described for membrane-stabilizing agents. This agent also demonstrated the capacity to produce differentiation in leukemia cell lines.

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Citations

Dec 31, 2003·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP Ramulu
Mar 12, 2010·Chemical Communications : Chem Comm·Mahesh HariharanBernd Epe
Mar 1, 2012·Organic and Medicinal Chemistry Letters·Debasish BandyopadhyayBimal K Banik
Jun 26, 2012·Organic and Medicinal Chemistry Letters·Rosario Astrid Vargas CárdenasBimal K Banik
Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohammad K MohammadiRamin Miri
Dec 3, 2014·European Journal of Medicinal Chemistry·Debasish BandyopadhyayBimal K Banik
Feb 11, 2016·Journal of Medicinal Chemistry·Lampros MilanosNuska Tschammer
Dec 8, 2009·European Journal of Medicinal Chemistry·Bimal K BanikFrederick F Becker
Oct 2, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debasish BandyopadhyayBimal K Banik Banik
Jun 20, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Sambasivarao KothaYuvaraj Dommaraju
Mar 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debasish BandyopadhyayBimal K Banik
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debasish BandyopadhyayBimal K Banik
Nov 16, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antara BanikBimal K Banik
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debasish BandyopadhyayBimal K Banik
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debasish BandyopadhyayBimal K Banik
Mar 15, 2015·Chemistry & Biodiversity·Chokkalingam UvaraniPalathurai Subramaniam Mohan
Aug 23, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohammad Mehdi HaghdoostAnnie Castonguay
Nov 1, 2010·Oncology Letters·Bimal K BanikFredrick F Becker
Jan 3, 2004·The Journal of Organic Chemistry·Bimal K BanikIndrani Banik
Dec 7, 2007·Journal of Medicinal Chemistry·Keiichiro OharaJean-Jacques Vasseur
Jul 15, 2020·Current Organic Synthesis·Biswa Mohan SahooPreetismita Borah
Dec 28, 2002·Journal of Medicinal Chemistry·Indrani BanikBimal K Banik

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