PMID: 6406782Mar 1, 1983Paper

Polycyclic hydrocarbon and polychlorinated biphenyl solubilization in aqueous solutions of mixed micelles

Lipids
J M Laher, J A Barrowman

Abstract

To determine the physiochemical behavior of xenobiotic hydrocarbons in simulated intestinal content, we examined the partition of 7,12-dimethylbenzanthracene (DMBA), 3-methyl cholanthrene (MC), benzo(a)pyrene, and a polychlorinated biphenyl compound (PCB, Aroclor 1242) between an emulsified oil phase and a mixed micellar solution. In a mixed lipid-bile salt system, negligible amounts of hydrocarbon were present in aqueous solution below the critical micellar concentration (CMC) of sodium taurocholate. Once the CMC was obtained, the 4 hydrocarbons exhibited nearly identical partitions from the lipid into the micellar system which was enhanced by increased concentrations of bile salt, reduction of triglyceride concentration and the formation of mixed rather than pure bile salt micelles. The partition of DMBA and MC into micelles was optimized by long-chain monounsaturated oleic acid and monooleoylglycerol as compared to their octanoic or linoleic counterparts. Linoleic acid and monolinoleoylglycerol maximized the partition of PCB from the oil into the micellar phase. In a mixed micellar system excluding an oil phase and an excess of DMBA, a molar saturation ratio (mol hydrocarbon:mol bile salt) was calculated by regression analys...Continue Reading

References

Apr 13, 1973·Biochimica Et Biophysica Acta·M el-Gorab
Jan 1, 1982·Bulletin of Environmental Contamination and Toxicology·J MesD Turton
Feb 1, 1981·Journal of Human Nutrition·J I Gray, I D Morton

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Citations

Jan 1, 1989·Progress in Lipid Research·J A BarrowmanB Borgstrom
Mar 16, 2013·Environmental Science and Pollution Research International·Margaret O James, Kevin M Kleinow
Jan 1, 1996·Journal of Pharmaceutical Sciences·J Horský, J Pitha
Jul 13, 2002·Journal of Pharmaceutical Sciences·Timothy Scott Wiedmann, Lamya Kamel
Mar 15, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Stefan de GelderMarc H G Berntssen
Jan 1, 1988·Annals of the New York Academy of Sciences·J M Laher, J A Barrowman
May 10, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Stefan de GelderPeter H M Klaren
Sep 24, 2004·Environmental Science & Technology·Ian M Voparil, Lawrence M Mayer

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