Polycystic ovarian morphology in postmenarchal adolescents

Fertility and Sterility
E CodnerFernando Cassorla

Abstract

To evaluate the association of polycystic ovary morphology (PCOM) with ovarian function in adolescents and to determine its time course during two years of follow-up. Prospective study. Academic center. Twenty healthy adolescents were followed from 2-4 years after menarche. We performed annual ultrasonographic and hormonal studies. Ovulation was assessed during 6 consecutive months by measuring salivary progesterone levels. Persistence of PCOM during the years following menarche; ovulation in girls with PCOM. PCOM was observed in 40%, 35%, and 33.3% of the ultrasonographic studies performed at 2, 3, and 4 years after menarche, respectively. The concordance between ultrasonographic diagnosis at 2 and 4 years postmenarche (50%) was nonsignificant (kappa = 0.08). PCOM was not associated with abnormalities in ovulatory rate, menstrual cycle duration, lipid levels, or homeostatic model assessment of insulin resistance. However, lower FSH (4.8 ± 1.3 vs. 6.1 ± 1.9 mUI/ml) were observed in girls with PCOM compared with those without PCOM. Similar T and stimulated 17-hydroxyprogesterone on the leuprolide test were observed in girls with and without PCOM. PCOM is an inconstant finding in healthy adolescents and does not appear to be asso...Continue Reading

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Citations

Sep 22, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Karina SotomayorFernando Cassorla
Jul 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Claudio VillarroelEthel Codner
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