Polycystic ovary syndrome: anomalies in progesterone production

Human Reproduction
N DoldiA Ferrari

Abstract

The underlying cause of anovulation and miscarriage in polycystic ovary syndrome (PCOS) is unknown. Progesterone may play an important role in oocyte fertilization and embryo implantation. Therefore, in this study we analyse the endocrine function of luteinizing granulosa cells to synthesize progesterone in vivo and in vitro in PCOS and normal patients participating in an in-vitro fertilization programme. Human luteinizing granulosa cells were obtained from 10 patients with normal ovaries (controls) and 10 patients with PCOS by follicular aspiration of individual follicles of each patient and pooled in an attempt to obtain three groups: cells from follicle sizes < or =10,>10< or =15 and > or =16. Serum concentrations of oestradiol and progesterone on the day of human chorionic gonadotrophin (HCG) injection were significantly higher (P < 0.01 and P < 0.05) in PCOS patients than in controls. After HCG stimulation, in-vitro progesterone production was enhanced in granulosa cells of the control group and concentrations increased with follicular size as expected. However, the concentration of progesterone of PCOS patients did not increase with follicular size and there was a significant difference between normal and PCOS groups in f...Continue Reading

Citations

May 17, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N DoldiA Ferrari
Oct 14, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ghamartaj HosseinMarziyeh Agha Hosseini
Feb 3, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Chebib ChekirYuji Hiramatsu
Jul 20, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·D Siassakos, P Wardle
Aug 20, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vittorio UnferGian Carlo Di Renzo
May 10, 2016·Reproductive Biomedicine Online·Qiong WangCan-Quan Zhou
Apr 30, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mustafa DemirBulent Yilmaz
Jan 24, 2002·Biology of Reproduction·K B C ApparaoBruce A Lessey
Oct 17, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mohamed RezkEl-Sayed El-Shamy
Jun 27, 2018·Journal of Molecular Endocrinology·Muraly Puttabyatappa, Vasantha Padmanabhan
Jun 4, 2005·Human Reproduction·Suhail A R DoiKamal A S Al-Shoumer
Oct 23, 2016·Reproductive Biology and Endocrinology : RB&E·Deepika Garg, Zaher Merhi

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