Polycystic ovary syndrome in the Indian Subcontinent

Seminars in Reproductive Medicine
Gautam N Allahbadia, Rubina Merchant

Abstract

Polycystic ovary syndrome (PCOS) is a complex, multifaceted, heterogeneous disorder that affects approximately 5 to 10% of women of reproductive age. It is characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance, hyperinsulinemia, abdominal obesity, hypertension, and dyslipidemia as frequent metabolic traits (metabolic syndrome) that culminate in serious long-term consequences such as type 2 diabetes mellitus, endometrial hyperplasia, and coronary artery disease. It is one of the most common causes of anovulatory infertility. However, the heterogeneous clinical features of PCOS may change throughout the life span, starting from adolescence to postmenopausal age, largely influenced by obesity and metabolic alterations, and the phenotype of women with PCOS is variable, depending on the ethnic background. The etiology of PCOS is yet to be elucidated; however, it is believed that in utero fetal programming may have a significant role in the development of PCOS phenotype in adult life. Though a woman may be genetically predisposed to developing PCOS, it is only the interaction of environmental factors (obesity) with the genetic factors that results in the characteristic metabolic ...Continue Reading

Citations

Aug 16, 2013·Obstetrical & Gynecological Survey·Jaya MehtaDaniel Dumesic
Dec 12, 2012·Indian Journal of Endocrinology and Metabolism·Ritu KaroliSumit Maini
Feb 16, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mohd Ashraf GanieAafia Rashid
Jun 25, 2009·Reproductive Biomedicine Online·Bon-Hee Gu, Kwang-Hyun Baek
Mar 24, 2012·Gynecologic and Obstetric Investigation·Kok-Min SeowJiann-Loung Hwang
May 27, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Madhavi PusalkarAnurupa Maitra

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