Polycystic ovary syndrome woman with heterozygous androgen receptor gene mutation who gave birth to a child with androgen insensitivity syndrome

Obstetrics & Gynecology Science
Hyoun NamHan-Wook Yoo

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, and it is a multifactorial polygenic disorder with a broad spectrum of clinical manifestations. Although pathogenesis is still unclear, androgen receptor (AR) gene polymorphism may be one of the etiologic factors of PCOS. AR gene polymorphism has been also associated with other forms of androgen pattern diseases. We report a PCOS woman with heterozygous AR gene mutation who gave birth to a baby with andorgen insensitivity syndrome.

References

Sep 28, 1995·The New England Journal of Medicine·S Franks
Jun 1, 1953·American Journal of Obstetrics and Gynecology·J M MORRIS
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Jun 17, 2008·Fertility and Sterility·Polonca FerkKsenija Gersak
Aug 13, 2008·Hormones : International Journal of Endocrinology and Metabolism·Angeliki GalaniAriadni Kalpini-Mavrou
Nov 28, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Lawrence H LinEdmund C Baracat

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Citations

Apr 20, 2018·Genetics Research International·Roshan DadachanjiSrabani Mukherjee
Apr 30, 2020·Saudi Journal of Biological Sciences·Salina Y Saddick

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Methods Mentioned

BETA
cesarean section

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