Polycystins and renovascular mechanosensory transduction.

Nature Reviews. Nephrology
Amanda Patel, Eric Honoré

Abstract

Autosomal dominant polycystic kidney disease is a common disorder, affecting approximately one in 1,000 individuals. This disease is characterized by the presence of renal and extrarenal cysts, as well as by cardiovascular abnormalities, including hypertension and intracranial aneurysms. Mutations in the PKD1 gene account for 85% of cases, whereas mutations in PKD2 account for the remaining 15% of cases. Findings from the past 10 years indicate that polycystins, the products of the PKD genes, have a key role in renal and vascular mechanosensory transduction. In the primary cilium of renal, nodal, and endothelial cells, polycystins are proposed to act as flow sensors. In addition, the ratio of polycystin-1 to polycystin-2 regulates pressure sensing in arterial myocytes. In this Review, we summarize the data indicating that polycystins are key molecules in mechanotransduction. Moreover, we discuss the role of nucleotide release and autocrine and/or paracrine purinergic signaling in both fluid flow and pressure responses. Finally, we discuss the possible role of altered mechanosensory transduction in the etiology of polycystic kidney disease.

References

Feb 1, 1974·Kidney International·G H FettermanF E Sherman
Apr 1, 1982·British Journal of Urology·D Derezic, L Cecuk
Oct 1, 1995·Journal of the American Society of Nephrology : JASN·G A TannerJ A McAteer
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·L TsiokasV P Sukhatme
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·P D WilsonE M Schwiebert
Apr 1, 1997·Journal of the American Society of Nephrology : JASN·M D GriffinR Kumar
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·V E TorresS Somlo
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·T P StosselS S Shapiro
Apr 17, 2001·Biochemical and Biophysical Research Communications·X Z ChenJ Zhou
Jul 4, 2001·Cerebrovascular Diseases·R T CheungK H Chan
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BoulterR Sandford
Nov 1, 2001·The Journal of Membrane Biology·H A Praetorius, K R Spring
Nov 9, 2001·Neurochemical Research·P Bodin, G Burnstock
Feb 2, 2002·Human Molecular Genetics·A PersuO Devuyst
Feb 21, 2002·Nature Cell Biology·Peter KoulenStefan Somlo
Mar 7, 2002·American Journal of Physiology. Renal Physiology·Erik M SchwiebertAmanda L Taylor
Jun 14, 2002·Current Biology : CB·Petra PennekampBernd Dworniczak
Jan 18, 2003·The Journal of Membrane Biology·H A Praetorius, K R Spring
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Jens Leipziger
Mar 21, 2003·The Journal of Membrane Biology·T Voets, B Nilius
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Qi QianVicente E Torres
Dec 5, 2003·Nature·David E Clapham
Jan 9, 2004·The New England Journal of Medicine·Patricia D Wilson
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Surya M Nauli, Jing Zhou
Sep 16, 2004·American Journal of Physiology. Renal Physiology·H A PraetoriusJ Leipziger
Jan 25, 2005·Nature Cell Biology·Rosario MarotoOwen P Hamill
Feb 16, 2005·Annual Review of Physiology·Helle A Praetorius, Kenneth R Spring
May 13, 2005·Pflügers Archiv : European journal of physiology·Patrick Delmas
May 17, 2005·Journal of Molecular Biology·Julia R FormanJane Clarke
Oct 13, 2005·The Journal of Biological Chemistry·Feng QianAndres Oberhauser
Dec 1, 2005·Differentiation; Research in Biological Diversity·Christina KarcherMartin Blum
Dec 13, 2005·Nature Reviews. Genetics·Friedhelm Hildebrandt, Edgar Otto
Dec 13, 2005·Nature Genetics·Evelyne FischerMarco Pontoglio
May 26, 2006·Annual Review of Genomics and Human Genetics·Jose L BadanoNicholas Katsanis
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jun 8, 2007·Journal of the American Society of Nephrology : JASN·Mikkel Erik Juul JensenJens Leipziger
Oct 24, 2007·Nature Reviews. Molecular Cell Biology·Manfred FliegaufHeymut Omran

❮ Previous
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Citations

May 31, 2013·Open Biology·Deepak Babu, Sudipto Roy
Jun 12, 2013·Annual Review of Neuroscience·Niels EijkelkampJohn N Wood
Feb 13, 2014·PloS One·Wanessa C LimaPierre Cosson
Nov 23, 2013·Purinergic Signalling·Geoffrey BurnstockMatthew A Bailey
Jul 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David MerrickMichael J Caplan
Nov 17, 2010·The Journal of Cell Biology·Hannah C Chapin, Michael J Caplan
Jun 26, 2012·European Journal of Cell Biology·Arthur J KuipersFrank N van Leeuwen
Mar 30, 2016·Pflügers Archiv : European journal of physiology·Joana Raquel MartinsSophie Demolombe
Aug 12, 2015·Nature Reviews. Nephrology·Ronald D PerroneTerry Watnick
Jan 25, 2011·Biochimica Et Biophysica Acta·Sara TerrynOlivier Devuyst
Apr 30, 2015·Biochimica Et Biophysica Acta·A R BattleB Martinac
Mar 21, 2013·Small GTPases·Alejo E Rodríguez-Fraticelli, Fernando Martín-Belmonte
Oct 29, 2013·Organogenesis·Paraskevi Goggolidou
Jul 1, 2014·Seminars in Cell & Developmental Biology·Robert O'HaganMaureen M Barr
Nov 2, 2014·Cell Death and Differentiation·I OrhonP Codogno
Dec 1, 2014·Bioscience·Hiroaki Ishikawa, Wallace F Marshall
May 28, 2016·Nature Cell Biology·Zsuzsanna Takacs, Tassula Proikas-Cezanne
Aug 12, 2017·Shock·Min LiuYugang Jiang
Apr 11, 2015·Circulation Research·Jay D HumphreyDianna M Milewicz
Aug 20, 2011·Journal of the American Society of Nephrology : JASN·Stine Falsig PedersenElse K Hoffmann
Oct 21, 2011·Physiological Reviews·Alberto DarszonClaudia L Treviño
May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Yong Joon Kim, Joon Kim
Aug 2, 2017·Pflügers Archiv : European journal of physiology·Esther GiehlBarbara E Ehrlich
Sep 17, 2017·Oncotarget·Daniel Peña-OyarzunAlfredo Criollo
Jul 13, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Roman-Ulrich Müller, Bernhard Schermer
Feb 9, 2017·Cellular and Molecular Life Sciences : CMLS·Steven J KunnenDorien J M Peters
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Aug 11, 2018·Science·Qiang SuYigong Shi
Feb 1, 2012·Clinical Kidney Journal·Farah Klingenberg-SalachovaFrans Boereboom
Mar 16, 2017·Cold Spring Harbor Perspectives in Biology·Kinga M BujakowskaEric A Pierce
Sep 2, 2020·Cell Communication and Signaling : CCS·Jizheng GuoBing Shen
Oct 11, 2017·Frontiers in Physiology·Noor M YassineSimon C Body
Aug 5, 2020·Journal of the American Society of Nephrology : JASN·Shohei KuraokaRyuichi Nishinakamura
Nov 2, 2017·Journal of Biological Physics·Vlado A BuljanRichard B Banati
Apr 6, 2019·Nature Reviews. Nephrology·Dominique DouguetEric Honoré

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