Polydatin inhibits the IL-1β-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis

Food & Function
Shangkun TangHaixiao Liu

Abstract

Osteoarthritis (OA), which is characterized by progressive degradation of the articular cartilage, is the most prevalent form of human arthritis. Accumulating evidence has shown that polydatin (PD) exerts special biological functions in a variety of diseases. However, whether it protects against OA development has remained unknown. Here, we investigated the anti-inflammatory and chondroprotective effects of PD on interleukin (IL)-1β-induced human osteoarthritic chondrocytes and in the surgical destabilization of medial meniscus mouse (DMM) OA models. In vitro, PD treatment completely suppressed the over-production of pro-inflammatory mediators, including prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), nitric oxide (NO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and IL-6 in IL-1β-induced human OA chondrocytes. Moreover, PD exerted a suppressive effect on the expression of matrix-degrading proteases, including matrix metalloproteinase 13 (MMP13) and thrombospondin motifs 5 (ADAMTS-5), which leads to the degradation of the extracellular matrix (ECM). Meanwhile, specific inhibition of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) level by short-interfering RNA (siRNA) strongly reversed the...Continue Reading

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Citations

Aug 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Feng HanDing Zhao
Nov 27, 2020·Osteoarthritis and Cartilage·Zhenxuan ShaoXiaolei Zhang
Apr 4, 2021·Nutrients·Francesca OlivieroRoberto Luisetto
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongsheng WangGuangjie Yang
Apr 23, 2021·Journal of Inflammation Research·Xiaofen HuQuanqing Wan
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan ChenDuo Li
Jul 3, 2018·Journal of Agricultural and Food Chemistry·Chuwen LiSimon Ming-Yuen Lee
Dec 23, 2021·Phytotherapy Research : PTR·Penghui YeYaoguang Guo

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay
protein assay
electrophoresis
PCR
transfection
nuclear translocation
X-ray
ubiquitination

Software Mentioned

Primer
SPSS
- Blast
Image J
Image Lab

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