Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NFκB signalling

Journal of Cellular and Molecular Medicine
Gan ZhaoXiu-Li Peng

Abstract

Staphylococcus aureus (S. aureus) causes severe inflammation in various infectious diseases, leading to high mortality. The clinical application of antibiotics has gained a significant curative effect. However, it has led to the emergence of various resistant bacteria. Therefore, in this study, we investigated the protective effect of polydatin (PD), a traditional Chinese medicine extract, on S. aureus lipoteichoic acid (LTA)-induced injury in vitro and in vivo. First, a significant improvement in the pathological conditions of PD in vivo was observed, suggesting that PD had a certain protective effect on LTA-induced injury in a mouse model. To further explore the underlying mechanisms of this protective effect of PD, LTA-induced murine macrophages were used in this study. The results have shown that PD could reduce the NF-κB p65, and IκBα phosphorylation levels increased by LTA, resulting in a decrease in the transcription of pro-inflammatory factors, such as TNF-α, IL-1β and IL-6. However, LTA can not only activate NF-κB through the recognition of TLR2 but also increase the level of intracellular reactive oxygen species (ROS), thereby activating NF-κB signalling. We also detected high levels of ROS that activate caspases 9 an...Continue Reading

References

Nov 1, 1980·The Biochemical Journal·J F Turrens, A Boveris
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Jan 23, 1999·Oncogene·S J Baker, E P Reddy
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SchoonbroodtJ Piette
Nov 9, 2000·Anaesthesia·P C Kam, N I Ferch
Apr 12, 2002·The Lancet Infectious Diseases·Isaac Ginsburg
May 18, 2004·Trends in Immunology·Giuseppina Bonizzi, Michael Karin
Sep 24, 2005·Nature Immunology·Frederick M Ausubel
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·I-Ta LeeChuen-Mao Yang
Feb 17, 2010·Nature Reviews. Microbiology·Sarah LebeerSigrid C J De Keersmaecker
May 25, 2010·Microbes and Infection·Ronan KapetanovicMinou Adib-Conquy
Apr 2, 2013·Archives of Toxicology·Krishnendu SinhaParames C Sil
Sep 14, 2013·Innate Immunity·Jennifer KaplanBasilia Zingarelli
Nov 6, 2014·Experimental and Therapeutic Medicine·Jinfen JuWeihon Li
Feb 24, 2015·Immunological Reviews·Günter Weiss, Ulrich E Schaible
Sep 21, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Jeffrey N JohnstonKristina G Hulten
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Huilian QiaoZhen Li
Mar 22, 2016·Oxidative Medicine and Cellular Longevity·Jixiang ZhangWeiguo Dong
Oct 30, 2016·Journal of Crohn's & Colitis·Cristiana PereiraFernando Magro
Apr 23, 2016·The Journal of Perinatal & Neonatal Nursing·Jan M Kriebs
May 5, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gan ZhaoGanzhen Deng
Jul 17, 2016·Advances in Nutrition·Sabine Weiskirchen, Ralf Weiskirchen
Aug 3, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qiu-Hong MengJian-Bo Wang
Aug 31, 2016·International Journal of Oncology·Eun-Ok ChoiYung Hyun Choi

❮ Previous
Next ❯

Citations

May 4, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kangfeng JiangGanzhen Deng
Jun 21, 2020·Journal of Cellular and Molecular Medicine·Tao ZhangChangwei Qiu
Nov 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin WangAizhong Zhang
Nov 11, 2019·Chemico-biological Interactions·Hong LiYali Zhang
May 20, 2020·Journal of Microbiology and Biotechnology·Wanying ZhangXiaofeng Jiang
Jul 25, 2020·Veterinary and Comparative Oncology·Tao ZhangChangwei Qiu
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming-Horng TsaiI-Ta Lee
Apr 29, 2021·Inflammation·Talha UmarGanzhen Deng
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Zhen-Dong ZhangJian-Yong Li
Dec 23, 2021·Phytotherapy Research : PTR·Penghui YeYaoguang Guo

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
PCR
transfection
Protein Assay
flow cytometry
nuclear translocation
ubiquitination

Software Mentioned

GraphPad Prism
Image
Primer Premier
Pro Plus
GraphPad InStat

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.