Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-κB pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jun ZouXingren Liu

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death. Particularly, inflammation is crucial for the progression of NSCLC. In the past few decades, the anti-tumor effects of some traditional Chinese medicinal herbs have caused much attention. This study was designed to investigate the effects of polydatin in the progression of NSCLC. CCK-8 assay, wound healing assay and western blot assay were used to assess the anti-cancer property. Consequently, we showed that polydatin inhibited proliferation and migration of NSCLC cells (A549 and H1299 cells) in a dose-dependent manner. In addition, polydatin suppressed the expression of NLRP3, ASC and pro-caspase-1in NSCLC cells. Activation of NLRP3 inflammasome counteracted the inhibitory effect of polydatin on proliferation and migration of NSCLC cells, suggesting that polydatin suppressed progression of NSCLC through inhibiting NLRP3 inflammasome activation. Furthermore, polydatin was found to down-regulate relative expression of phosphor-NF-κB p65 and activation of NF-κB pathway by TNF-α also abolished the inhibitory effect of polydatin on proliferation and migration of NSCLC cells. In conclusion, our data showed that polydatin acted as an anti-tumor agent to suppress...Continue Reading

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Citations

Nov 23, 2019·Cancer Biotherapy & Radiopharmaceuticals·Ye JinLingli Yu
Dec 12, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jinhua DaiGuofang Chen
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Aug 25, 2021·Cellular & Molecular Biology Letters·Ghazaleh Khalili-Tanha, Meysam Moghbeli
Aug 28, 2021·Biomolecules·Juwon LeeYong Sang Song

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