Polydeoxyribonucleotide improves tendon healing following achilles tendon injury in rats

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Shin Hyuk KangSeung Hwan Chang

Abstract

Tendon injuries are major musculoskeletal disorders. Polydeoxyribonucleotide activates the adenosine receptor subtype A2A, resulting in tissue growth and neogenesis. This experimental study confirms that polydeoxyribonucleotide can improve secretion of various growth factors, promote collagen synthesis, and restore tensile strength of the Achilles tendon in a rat model with Achilles tendon injury. Thirty-six male Sprague-Dawley rats, aged 7 weeks, were divided into two groups, and the Achilles tendon was transected and repaired using the modified Kessler's method. In the experimental group (n = 18), the rats received daily intraperitoneal administration of polydeoxyribonucleotide (8 mg/kg/day for 1, 2, or 4 weeks). The control groups received the same amount of normal saline. The rats were euthanized at 1, 2, and 4 weeks, and tissues from the repair site were harvested. The cross-sectional area of the tendon was significantly increased at 2 and 4 weeks in polydeoxyribonucleotide group (p = 0.008 and p = 0.017, respectively). Moreover, tendons in the polydeoxyribonucleotide group were more resistant to mechanical stress at 2 and 4 weeks (p = 0.041 and p = 0.041, respectively). The staining levels of collagen type I in the experi...Continue Reading

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Citations

Mar 1, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shanshan XieHongbin Lu
May 18, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Kyoungho RyuSung Hyun Lee
Oct 10, 2020·Scientific Reports·Da Yong ShinSeol-Ha Jeong
Dec 4, 2020·International Neurourology Journal·Jeong Ho RhoJin Hee Han

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