Polydispersity controls the strength of semi-flexible polymer networks

Physical Biology
Mohammad TehraniAlireza Sarvestani

Abstract

The classical theory of polymer elasticity is built upon the assumption of network monodispersity-the premise that polymer networks are comprised of sub-chains of equal length. The crosslinking of biopolymers, however, is a random process and the resultant networks are likely to be polydisperse. The effect of structural polydispersity on the mechanical behavior of biopolymer networks is not well understood. The purpose of this contribution is to show how network polydispersity controls mechanical behavior and the ultimate properties of crosslinked semi-flexible filaments at finite deformations. The proposed micromechanical continuum model is based on the force-elongation relation of individual chains of different lengths. It is shown that the mechanical strength of the network is controlled by the finite-extensibility of filaments and the degradation of shorter filaments at relatively small stretches. The progressive failure of filaments continues and eventually determines the ultimate strength of the network. The predicted stress-stretch behaviors are in reasonable agreement with the experimental data for connective tissues.

References

Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J ManiotisD E Ingber
Mar 3, 1999·Journal of Biomechanics·H Liao, S M Belkoff
Dec 11, 1995·Physical Review Letters·F C MacKintoshP A Janmey
Jun 12, 2002·Molecular Biology of the Cell·Joseph Ostashevsky
Jun 27, 1959·Nature·M L HARKNESS, R D HARKNESS
Feb 3, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·D A HeadF C MacKintosh
Jul 21, 2004·The American Journal of Sports Medicine·Sanjitpal S GillMark D Miller
Feb 8, 2005·Medical Engineering & Physics·A N NataliG Taglialavoro
Jul 8, 2005·Journal of Biomechanics·James H-C Wang
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Markus J Buehler
Aug 26, 2006·Biomechanics and Modeling in Mechanobiology·Raffaella De Vita, William S Slaughter
Mar 8, 2008·Acta Biomaterialia·Jeffrey S Palmer, Mary C Boyce
Aug 12, 2009·Medical Engineering & Physics·Zheying Guo, Raffaella De Vita
Nov 10, 2009·Journal of the Royal Society, Interface·Yuye TangSteven J Eppell
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Stefan B LindströmDavid A Weitz
Jul 20, 2011·Biomechanics and Modeling in Mechanobiology·P SáezM A Martínez
Sep 4, 2012·Journal of Biomechanical Engineering·Mohammad F HadiVictor H Barocas
Sep 25, 2012·Soft Matter·Qi WenA G Yodh
Apr 23, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Michael J UnterbergerGerhard A Holzapfel
Jul 7, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Vincent R ShermanMarc A Meyers

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review Letters
F C MacKintoshPaul A Janmey
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Sitikantha Roy, H Jerry Qi
Proceedings of the National Academy of Sciences of the United States of America
J H ShinD A Weitz
Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
J HendricksW Zimmermann
© 2022 Meta ULC. All rights reserved