PMID: 9662476Jul 14, 1998Paper

Polydnavirus-mediated inhibition of lysozyme gene expression and the antibacterial response

Insect Molecular Biology
Kent S ShelbyBruce A Webb

Abstract

Parasitism of lepidopteran host larvae by hymenopteran parasitoids impairs the cellular immune response via expression of polydnavirus genes. Encapsulation of parasitoid eggs is thereby prevented. Parasitized insects are susceptible to opportunistic infections, suggesting that additional components of the immune system are affected. Insects normally respond to infection by inducing the synthesis of an array of antibacterial factors, including cecropins and lysozyme via a NFkappaB/lkappaB-like signal transduction pathway. To characterize the effects of PDVs on the antibacterial immune response, plasma antibacterial activities were assayed in H. virescens larvae infected with the C. sonorensis PDV. Plasma lysozyme activity in Heliothis virescens was reduced in parasitized and PDV-infected larvae after immune challenge. To examine the regulation of lysozyme after CsPDV injection, the Heliothis virescens lysozyme cDNA was cloned. In contrast to plasma lysozyme activity, the 1.1 kb lysozyme mRNA was induced in fat body and haemocytes by known elicitors. The data suggest that CsPDV, like some other viruses, regulates host cell gene expression at the level of translation. We propose that the immunodeficiencies caused by CsPDV injectio...Continue Reading

Citations

May 29, 2003·Journal of Insect Physiology·K S. Shelby, B A. Webb
May 29, 2003·Journal of Insect Physiology·K T. Chung, D D. Ourth
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S FujimotoI Morishima
Jul 2, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sangki Bae, Yonggyun Kim
Mar 21, 2002·Insect Molecular Biology·R J MunksM J Lehane
Dec 4, 2003·Annual Review of Entomology·Jeremy A Kroemer, Bruce A Webb
Mar 19, 2014·FEBS Letters·Daniel K Hasegawa, Matthew W Turnbull
Sep 25, 2012·Developmental and Comparative Immunology·Kayvan EtebariSassan Asgari
Mar 10, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Karen P Barandoc, Yonggyun Kim
May 16, 2009·Journal of Invertebrate Pathology·Kent S Shelby, Holly J R Popham
Apr 21, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Karen P Barandoc, Yonggyun Kim
Oct 8, 2008·Archives of Insect Biochemistry and Physiology·Kent S Shelby, Holly J R Popham
Nov 13, 2004·Trends in Microbiology·Richard V GlatzOtto Schmidt
May 29, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sangki Bae, Yonggyun Kim
Apr 4, 2006·Journal of Insect Physiology·Angelika Fath-GoodinBruce A Webb
Feb 8, 2006·Virus Research·Catherine DupuyJean-Michel Drezen
Oct 16, 2009·Molecular Immunology·Michael ChapelleBernard Duvic
Sep 26, 2006·Advances in Virus Research·Torrence A GillBruce A Webb
Aug 10, 2018·The Journal of General Virology·Peng Zhang, Matthew W Turnbull
Jun 22, 2000·The Journal of General Virology·C BéliveauG Bellemare
Jan 13, 2017·Journal of Insect Physiology·Daniel K HasegawaMatthew W Turnbull
Apr 8, 2000·Journal of Invertebrate Pathology·K S ShelbyB A Webb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.