Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy

Scientific Reports
Arjun Prasad TiwariCheol Sang Kim

Abstract

We report a design and fabricate multifunctional localized platform for cancer therapy. Multiple stimuli-responsive polydopamine (PDA) was used for surface modification of electrospun doxorubicin hydrochloride (DOX) loaded polycaprolactone (PCL) fibers to make a designated platform. Photothermal properties such as photothermal performance and stability of the resulting composite mats were studied under the irradiation of the near-infrared (NIR) laser of 808 nm. With the incorporation of PDA into the fiber, a remarkable increase of local temperature was recorded under NIR illumination in a concentration-dependent manner with excellent stability. Drug released assay results revealed PDA coated PCL-DOX mats showed pH and NIR dual responsive behavior thereby exhibiting improved drug release in an acidic medium compared to physiological pH condition (pH 7.4) which is further increased by NIR exposure. The cancer activity in vitro of the mats was evaluated using cell counting (CCK) and live and dead cell assays. The combined effect of NIR mediated hyperthermia and chemo release resulting improved cells death has been reported. In summary, this study presents a major step forward towards a therapeutic model to cancer treatment utilizi...Continue Reading

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May 18, 2018·Journal of Nanoscience and Nanotechnology·Arjun Prasad TiwariCheol Sang Kim
May 29, 2018·ACS Applied Materials & Interfaces·Arjun Prasad TiwariCheol Sang Kim

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Citations

May 30, 2021·Advanced Materials·Hee Jung KimEunkyoung Kim
Apr 8, 2020·ACS Applied Materials & Interfaces·Elizabeth G Graham-GuryshKristy M Ainslie
Dec 18, 2021·ACS Applied Materials & Interfaces·Lei ChenLinge Wang

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Methods Mentioned

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scanning electron microscopy
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confocal microscopy
imaging technique

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