Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

ACS Applied Materials & Interfaces
Youxing ChengLei Ren

Abstract

This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO3@PDA NPs, for example, we found that the longitudinal relaxivity (r1) of MnCO3 NPs can improve from 5.7 to 8.3 mM-1 s-1. Subsequently, in vitro MRI and PTT results verified that MnCO3@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO3@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photother...Continue Reading

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Citations

Jul 5, 2019·Advanced Materials·Devleena SamantaChad A Mirkin
Aug 7, 2020·Nanomaterials·Chiara CavalliniLuca Menichetti
Dec 13, 2019·Biomaterials Research·Jihyo ParkSeonki Hong
Oct 20, 2020·Advanced Therapeutics·Corrine Ying Xuan ChuaAlessandro Grattoni
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Jan 3, 2021·Colloids and Surfaces. B, Biointerfaces·Hanmei LiQiang Peng
May 24, 2021·Journal of Photochemistry and Photobiology. B, Biology·Yunsu MaDongzhi Yang
Dec 27, 2017·ACS Applied Materials & Interfaces·Kefyalew Dagnew AddisuHsieh-Chih Tsai
May 7, 2019·Accounts of Chemical Research·Lok Wai Cola HoChung Hang Jonathan Choi
Mar 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Peng WangXiangyang Shi

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