Polydopamine-Decorated Sticky, Water-Friendly, Biodegradable Polycaprolactone Cell Carriers

Macromolecular Bioscience
Minhee KimJae-Hyung Jang

Abstract

A bioinspired adhesive material, polydopamine (pDA), was employed as an interfacial glue to stably immobilize human neural stem cells (hNSCs) on the external surface of biodegradable polycaprolactone (PCL) microspheres, thereby serving as versatile key systems that can be used for cell carriers. The pDA decoration on the PCL microspheres has been resulted in robust hNSC immobilization as well as proliferation on their curved surfaces. The pDA coating has transformed the hydrophobic PCL systems toward water-friendly and sticky characteristics, thereby resulting in full dispersion in aqueous solution and stable adherence onto a wet biological surface. Adeno-associated virus, a safe gene vector capable of effectively regulating cell behaviors, can be decorated on the PCL surfaces and delivered efficiently to hNSCs adhered to the microsphere exteriors. These distinctive multiple benefits of the sticky pDA microspheres can provide core technologies that can boost the therapeutic effects of cell therapy approaches.

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Citations

Aug 5, 2020·Journal of Tissue Engineering and Regenerative Medicine·Rui M DuarteAna Rita C Duarte
Feb 22, 2018·ACS Applied Materials & Interfaces·Ji Hyun RyuHaeshin Lee
Aug 21, 2021·ACS Applied Materials & Interfaces·Gabrielle ReyAli Dhinojwala
May 28, 2016·Nanomedicine·Zhanpeng ZhangPeter X Ma

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