Polydopamine particles as nontoxic, blood compatible, antioxidant and drug delivery materials

Colloids and Surfaces. B, Biointerfaces
Nurettin SahinerWayne F Reed

Abstract

Herein, the potential biomedical application of poly(3,4-dihyroxyphenyl)ethylamine, (poly(dopamine)-p(DA)) particles is reported. P(DA) particles with the size about 100 nm, 18.05 m2/g specific surface area, and mesoporous structure (7.19 nm pore width) were prepared and shown to be chemically modifiable using chlorosulfonic acid (CSA) and 3-CHloro-2 hydroxypropyl) trimethylammonium chloride solution (CHPACl) to obtain sulfonic acid and quaternary amine group containing modified p(DA) particles, m-p(DA)-CSA and m-p(DA)-CHPACl particles, respectively. The hydrolytic degradation of p(DA) particles at different pHs, including 1, 7.4 and 11, was carried out at 37.5 °C. These degradation studies revealed that p(DA) is slightly degradable at pH 1 and pH 7.4 with weight losses of 13.01 ± 0.08% and 7.26 ± 0.23% in 11 days, respectively. At pH 11, a sustained degradation that is almost linear degradation with time was observed for up to 30 days, with a total weight loss of 21.42 ± 0.88%. Furthermore, p(DA) particles were tested for cell toxicity against COS-1 cells and found non-toxic up to 50 μg/mL with 95.6 ± 4.5% cell viability as compared to 37.5 ± 0.03% for DA molecules. The p(DA) particles and DA were also compared for their abili...Continue Reading

Citations

Jul 16, 2020·Physical Chemistry Chemical Physics : PCCP·Juan Sebastian PappalardoRafik Naccache
Jan 10, 2021·Nanomaterials·Lucia CavigliFulvio Ratto
Feb 21, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hamid Hashemi-MoghaddamHamid Madanchi
Sep 1, 2021·Gels·Sahin DemirciNurettin Sahiner

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