Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

Biomaterials Science
Shaohan ZhangJun Wu

Abstract

Oxidative damage generated by various biochemical pathways can disrupt the oxidant/antioxidant balance in cells, causing slow wound healing and tissue regeneration; in this regard, a hydrogel dressing with antioxidant properties can promote wound healing; however, its design is still a challenge. Herein, a polydopamine/puerarin (PDA/PUE) nanoparticle-incorporated polyethylene glycol diacrylate hybrid hydrogel (PEG-DA/PDA/PUE) with antioxidant properties was prepared and used as a wound-healing material. Experimental observations indicated that the PEG-DA/PDA/PUE hydrogel possessed excellent swelling capacity and mechanical property. Moreover, the antioxidant capability was enhanced with an increase in the concentration of polydopamine/puerarin nanoparticles in the hydrogel. The hydrogel presented good cell proliferation and antioxidant activity, including a decrease in ROS and increase in the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity under oxidative stress conditions. Furthermore, the full-thickness skin-defect-regeneration process could be accelerated via the antioxidant hydrogel treatment. This study validated the potential applications of an antioxidant hydrogel for wound healing.

References

Apr 9, 2013·International Journal of Biological Macromolecules·Zhipeng GuXixun Yu
Oct 2, 2013·The Journal of Surgical Research·Jia-Wei WangYu Ding
Jun 16, 2015·Nature Medicine·Siu Ling WongDenisa D Wagner
Dec 24, 2015·Advanced Materials·Steven A CastleberryPaula T Hammond
Jan 23, 2016·ACS Applied Materials & Interfaces·Donghui LiangRong Chen
May 26, 2016·ACS Applied Materials & Interfaces·S Geetha PriyaAshok Kumar
Apr 20, 2017·Biomacromolecules·Ivaylo StefanovTzanko Tzanov
May 30, 2017·ACS Applied Materials & Interfaces·Xiaoyu MuXiao-Dong Zhang
Jan 18, 2018·Nature Communications·Vadims ParfejevsLukas Sommer
Mar 24, 2018·Advanced Drug Delivery Reviews·Robert DimatteoTatiana Segura
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arun Prabhu RameshbabuSantanu Dhara
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ivaylo StefanovTzanko Tzanov
May 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guixue XiaXiguang Chen

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Citations

Aug 7, 2020·Nanomaterials·Chiara CavalliniLuca Menichetti
Aug 19, 2020·Biomaterials Science·Junfei HuYiwen Li
Sep 18, 2020·Chemical Communications : Chem Comm·Yasun JingWenliang Li
Oct 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yunfen GaoJun Wu
Oct 28, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry· Priyanka, Anil Kumar
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Irving Fernández-CervantesVictor M Castaño-Meneses
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shima TavakoliJamal Moshtaghian
Jan 13, 2021·Biomaterials Science·Heni WangJun Wu
Feb 5, 2021·Biomaterials Science·Jie LiuJun Wu
Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qin ChenChangsheng Zhao
May 21, 2021·Biomaterials Science·Zejun XuJun Wu

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Methods Mentioned

BETA
fluorescence microscopy
flow cytometry
MDA

Software Mentioned

Origin

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