Polyelectrolyte and Antipolyelectrolyte Effects for Dual Salt-Responsive Interpenetrating Network Hydrogels

Biomacromolecules
Kang-Ting HuangChun-Jen Huang

Abstract

This work presents a salt-responsive interpenetrating network (IPN) hydrogel with effective antimicrobial properties and surface regeneration. The hydrogels were engineered using the double network strategy to form loosely cross-linked zwitterionic poly(sulfobetaine vinylimidazole) (pSBVI) networks into the highly cross-linked cationic poly((trimethylamino)ethyl methacrylate chloride) (pTMAEMA) framework via photopolymerization. The pTMAEMA/pSBVI hydrogel has strong mechanical properties, with a fracture stress 120× higher than single network pTMAEMA hydrogel. In addition, there is inverse correlation between elastic modulus and elastic strain of pTMAEMA/pSBVI hydrogels as a function of ionic strength. The cationic pTMAEMA and zwitterionic pSBVI show opposite swelling behaviors in salt solutions due to the polyelectrolyte effect and antipolyelectrolyte effect. Therefore, the pTMAEMA/pSBVI hydrogel elicits a significant interfacial transition in solutions with different ionic strengths. The IPN hydrogels have switchable lubrication and optical transmittance between deionized water and 1.0 M NaCl solution. The protein adsorption tests further confirmed the switchable interface of salt-responsive IPN hydrogels. In addition, bacter...Continue Reading

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Citations

Jul 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kang-Ting HuangChun-Jen Huang
Feb 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feng-Mei ChengHai-Dong Li
Feb 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zongyu XieXiaojing Wang
Feb 17, 2021·ACS Biomaterials Science & Engineering·Cheng-Chen YangYung Chang
Mar 27, 2021·ACS Nano·Woojin ChoiJinkee Hong
Apr 2, 2021·Journal of the American Chemical Society·Jing ZhaoTodd Emrick
Feb 19, 2020·Biomacromolecules·An WangYangbing Wen
Dec 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaojun LiQingye Liu

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