Polyelectrolyte complex nanoparticles based on chitosan and methoxy poly(ethylene glycol) methacrylate-co-poly(methylacrylic acid) for oral delivery of ibuprofen

Colloids and Surfaces. B, Biointerfaces
Yong-Li ShiJingjing Cao

Abstract

In this study, the copolymer of methoxy poly(ethylene glycol) methacrylate-co-poly(methylacrylic acid) [poly(mPEGMA-co-MAA)] was synthesized via radical polymerization. Based on this copolymer, novel chitosan-modified poly(mPEGMA-co-MAA) nanoparticles (CS/NPs) were developed to improve the bio-availability of ibuprofen (IBU). Fourier transform infrared spectroscopy (FTIR) and 1H nuclear magnetic resonance (1H NMR) spectra were used to confirm the synthesis of the copolymers. The morphology of CS/NPs was investigated with transmission electron microscopy (TEM). Thermogravimetric analysis (TGA) was used to reveal the thermodynamic properties of the CS/NPs. The cytotoxicity of CS/NPs was assessed by the cell viability of 293T cells. FTIR and 1H NMR spectra confirmed the synthesis of the novel copolymer. TEM photographs showed that the CS/NPs had a core-shell structure. High cell viability indicated that the CS/NPs were nontoxic. The in vitro release profiles suggested that the CS/NPs released IBU in pH 7.4 buffer in a continuous manner. Furthermore, the IBU-CS/NPs showed a long antifebrile effect. Animal experiments showed that the IBU-CS/NPs had obvious antifebrile effects. Therefore, CS/NPs could reduce the dosing frequency of I...Continue Reading

References

Jan 12, 1980·The Medical Journal of Australia·P M BrooksR Geddes
Apr 22, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Patricia de Albuquerque Garcia RedondoJosé Andrés Morgado-Díaz
Jul 23, 2005·International Journal of Clinical Practice. Supplement·Frank Bradbury
Sep 20, 2005·Advanced Drug Delivery Reviews·Hirofumi TakeuchiYoshiaki Kawashima
Jul 11, 2006·International Journal of Pharmaceutics·Amit KumarHarpal Singh
Jun 24, 2009·Colloids and Surfaces. B, Biointerfaces·Hongli ChenYinsong Wang
Sep 17, 2010·Journal of Pharmaceutical Sciences·Joanna S StevensSven L M Schroeder
Jul 9, 2013·Journal of Biomaterials Science. Polymer Edition·Qing ShangYongli Shi
Apr 8, 2015·Antimicrobial Agents and Chemotherapy·Sofia Costa-de-OliveiraCidália Pina-Vaz
Jul 15, 2015·The Physician and Sportsmedicine·Alfonso E BelloRobert J Holt
Dec 10, 2015·International Journal of Biological Macromolecules·Hassan H H HefniSalah M Tawfik
Jan 8, 2017·Inflammopharmacology·Dipak J Kanabar
Jan 15, 2017·Colloids and Surfaces. B, Biointerfaces·Anna PawlikGrzegorz D Sulka
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pingsheng HuangAnjie Dong

❮ Previous
Next ❯

Citations

Apr 18, 2021·Journal of Biomaterials Science. Polymer Edition·Xingyue DengFei Liang
Oct 24, 2018·Journal of the American Chemical Society·Vikramjit S RatheeJonathan K Whitmer
Oct 5, 2021·Journal of Biomaterials Science. Polymer Edition·Xiao HanGuoquan Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.