Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application

International Journal of Biological Macromolecules
Débora P FacchiAlessandro F Martins

Abstract

Hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. Tanfloc (TN) presents high aqueous solubility at pHs lower than 10; it contains substituted amino sites and molar weight of ca. 600,000gmol(-1). A factorial design (2(2)) was used to optimize the yield of alginate/tanfloc polyelectrolyte complexes (PECs). Dialysis recovered the overplus of alginate (AG) no complexed with TN. These materials were characterized by thermal analyses (TGA/DTG and DSC), zeta potential, and FTIR, while SEM technique depicted a rough surface on AG/TN complex, containing non-homogeneous pores. Indeed, the AG and TN were tailored to elicit scaffold materials with outstanding cytocompatibility, mainly upon mouse preosteoblastic cells because of reconstruction of bone tissues (119% at 10days). The AG/TN complex also displayed antioxidant and bactericidal activities against Staphylococcus aureus (S. aureus). Besides, the pristine TN fostered bacteriostatic and bactericidal performances towards S. aureus and Escherichia coli. However, for our best knowledge, no studies were still carried out on TN and TN-based materials for medical purpose.

Citations

Jan 8, 2020·Journal of Biomedical Materials Research. Part a·Roberta M SabinoKetul C Popat
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ann-Kathrin KoopmannNicola Hüsing
Apr 30, 2021·International Journal of Biological Macromolecules·Késsily B RufatoAlessandro F Martins
Feb 29, 2020·International Journal of Biological Macromolecules·Liszt Y C MadrugaMatt J Kipper
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariel C de OliveiraAlessandro F Martins
Nov 4, 2021·The Science of the Total Environment·Caroline Fiório GriloValéria da Silva Quaresma
Nov 18, 2021·Advanced Healthcare Materials·Liszt Y C Madruga, Matt J Kipper

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