Poly(epsilon-caprolactone)/chitin and poly(epsilon-caprolactone)/chitosan blend films with compositional gradients: fabrication and their biodegradability

Macromolecular Bioscience
Tomonori HonmaYoshio Inoue

Abstract

Poly(epsilon-caprolactone) (PCL)/chitin and PCL/chitosan blend films with compositional gradients were successfully fabricated by a dissolution/diffusion method; that is, repeatedly pouring the PCL/chitin (or PCL/chitosan) blend solutions, with variable composition, onto polysaccharide layers. The compositional gradient structure in the resulting films was characterized by polarized optic microscopy, ATR-FT-IR and trans-FT-IR microscopic spectroscopy. Enzymatic degradability of the PCL/chitin and PCL/chitosan blend films with compositional gradients in the presence of lysozyme was compared with those of homogeneous films and two-layer films. It was found that the degradation rate of PCL/chitin blend films with a compositional gradient was far lower than that of the neat chitin film, whereas the degradation rate of PCL/chitosan blend films with a compositional gradient was close to that of the neat chitosan film. The suppression of the chitosan crystallization, which accelerates the enzymatic degradation, at the surface of PCL/chitosan films with a compositional gradient was much more severe than that for PCL/chitin films with a compositional gradient.

References

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Citations

Mar 19, 2009·Macromolecular Rapid Communications·Kenichi YamazakiKoji Yazawa
Jan 28, 2009·Journal of Biomedical Materials Research. Part a·Hua WuRui Zhang
Jan 30, 2010·Journal of Tissue Engineering and Regenerative Medicine·Albino MartinsNuno M Neves
Sep 17, 2019·Colloids and Surfaces. B, Biointerfaces·Pritam DasLoredana De Bartolo
Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Pritam DasPatrice Bacchin

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