Polyester-based microdisc systems for sustained release of neuroprotective phosphine-borane complexes

Pharmaceutical Development and Technology
David A JanusLeonard A Levin

Abstract

Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived, necessitating the development of sustained-release formulations of these novel molecules. We screened a library of biodegradable co- and non-block polyester polymer systems for release of incorporated phosphine-borane complexes to evaluate them as drug delivery systems for use in chronic disease. Bis(3-propionic acid methyl ester)phenylphosphine borane complex (PB1) was combined with biodegradable polymers based on poly(D,L-lactide) (PDLLA), poly(L-lactide) (PLLA), poly(caprolactone) (PCL), poly(lactide-co-glycide) (PLGA), or poly(dioxanone-co-caprolactone) (PDOCL) to make polymer microdiscs, and release over time quantified. Of 22 polymer-PB1 formulations tested, 17 formed rigid polymers. Rates of release differed significantly based on the chemical structure of the polymer. PB1 released from PLGA microdiscs released most slowly, with the most linear release in polymers of 60:40 LA:GA, acid endcap, Mn 15 000-25 000 and 75:25 LA:GA, acid endcap, Mn 45 000-55 000. Biodegradable polymer systems can, therefor...Continue Reading

References

Mar 1, 1985·Journal of Biomedical Materials Research·G E VisscherG J Argentieri
Jan 1, 1995·Critical Reviews in Therapeutic Drug Carrier Systems·H Okada, H Toguchi
Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·H U SimonF Levi-Schaffer
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Kyle I SwansonLeonard A Levin
Mar 28, 2006·Investigative Ophthalmology & Visual Science·Christopher J LievenLeonard A Levin
Jan 29, 2010·Drugs & Aging·Noriyuki Kuno, Shinobu Fujii
May 25, 2010·Brain : a Journal of Neurology·Akiyasu KanamoriLeonard A Levin
Jun 11, 2010·Pharmaceutical Research·Susan S LeeMichael R Robinson
Oct 22, 2010·Current Eye Research·Nikhil Kumar PalakurthiRupak K Banerjee
Aug 22, 2012·Pharmaceutical Research·Muhammad Sajid Hamid AkashShuqing Chen
Jun 7, 2016·Neurochemistry International·Nicholas J NiemuthLeonard A Levin
Oct 19, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Shih-Feng Chou, Kim A Woodrow

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