Poly(ethylene glycol)-block-poly(ε-caprolactone)-and phospholipid-based stealth nanoparticles with enhanced therapeutic efficacy on murine breast cancer by improved intracellular drug delivery

International Journal of Nanomedicine
Xiaodan HeXuehua Jiang

Abstract

Effective anticancer drug delivery to the tumor site without rapid body clearance is a prerequisite for successful chemotherapy. 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-(methoxy[polyethyleneglycol]-2000) (DSPE-PEG2000) has been widely used in the preparation of stealth liposomes. Although PEG chains can efficiently preserve liposomes from rapid clearance by the reticuloendothelial system (RES), its application has been hindered by poor cellular uptake and unsatisfactory therapeutic effect. To address the dilemma, we presented a facile approach to fabricate novel stealth nanoparticles generated by poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL), soybean phosphatidylcholine (SPC), and cholesterol, namely LPPs (L represented lipid and PP represented PEG-b-PCL), for the delivery of anticancer drug paclitaxel (PTX). LPPs were prepared using the thin film hydration method. Two PEG-b-PCL polymers with different molecular weights (MW; PEG2000-b-PCL2000, MW: 4,000 Da and PEG5000-b-PCL5000, MW: 10,000 Da) were used to fabricate stealth nanoparticles. Conventional PEGylated liposome (LDP2000, L represented lipid and DP2000 represented DSPE-PEG2000) composed of SPC, cholesterol, and DSPE-PEG2000 was used as the cont...Continue Reading

Citations

Sep 3, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
Jul 2, 2016·Pharmacological Reviews·Phatsapong YingchoncharoenDes R Richardson
Feb 4, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Radosław GóreckiClaus Hélix-Nielsen
Dec 12, 2017·Biomacromolecules·Maureen R NewmanDanielle S W Benoit

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Methods Mentioned

BETA
dynamic light scattering
flow cytometry
dynamic dialysis
nuclear magnetic resonance

Software Mentioned

DAS

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