PMID: 2492771Feb 1, 1989Paper

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

The American Journal of Physiology
T H LiuC Y Hsu

Abstract

Superoxide dismutase and catalase enzymatically scavenge superoxide and hydrogen peroxide, respectively. Conjugation of polyethylene glycol to superoxide dismutase (PEG-SOD) or catalase (PEG-CAT) prolongs the circulatory half-life of the native enzymes and enhances their intracellular access. We studied the protective effect of these free radical scavengers on ischemic brain injury using a rat model of focal cerebral ischemia, which is suitable for therapeutic trials. Intravenous administration of PEG-SOD (10,000 U/kg) and PEG-CAT (10,000 U/kg) before ischemia reduced the infarct volume (treatment, 139 +/- 9 mm3, means +/- SE, N = 38; placebo, 182 +/- 8 mm3, n = 37, P less than 0.002). This finding supports the concept that superoxide and hydrogen peroxide contribute to brain injury following focal cerebral ischemia.

Citations

Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·R TakeshimaR J Traystman
Feb 23, 2012·British Journal of Pharmacology·Marta ArmogidaNicola Biagio Mercuri
Aug 28, 2010·Computer Methods in Biomechanics and Biomedical Engineering·Jaetak LeeKyungsook Han
Feb 17, 2018·Frontiers in Cellular Neuroscience·Emma V JonesKeith K Murai
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·H W PfisterA Tomasz
Aug 10, 2004·The Journal of Experimental Biology·David S WarnerInes Batinić-Haberle
Mar 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R Muzykantov

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