PMID: 2499100Jan 1, 1989Paper

Polyethylene glycol effect on the oxygenated and hypoxic isolated perfused rat kidney

Virchows Archiv. A, Pathological Anatomy and Histopathology
J KopolovicS Rosen

Abstract

Polyethylene glycol protects against O2 deprivation after clamping of the renal artery or norepinephrine infusion and in hypoxic primary cell culture. Isolated perfused kidneys under hypoxic conditions develop morphological alterations in all segments of the proximal tubule and medullary thick ascending limb. In an attempt to ameliorate the effect of hypoxia, rat kidneys were perfused for 90 min with regularly oxygenated (95% O2 + 5% CO2) or hypoxic perfusate (95% N2 + CO2) supplemented with 8-12% polyethylene glycol (MW approximately 8000). In oxygenated and hypoxic kidneys, polyethylene glycol produced similar changes in S1-S2 segments consisting of reduction of cell thickness and organelle compaction with internalization of brush border into the tubulo-vesicular system. In the S3 segment, the cellular volume loss was more limited; the brush border was transformed to membranous whorls and the cytoplasm contained large, irregular, clear zones. Mitochondrial swelling was pronounced in the hypoxic proximal tubules. Polyethylene glycol quantitatively increased and emphasized the damage in the medullary thick ascending limb. Inclusion of 10(-2) M ouabain preserved the medullary thick ascending limb from hypoxic injury and polyethy...Continue Reading

References

Aug 1, 1979·Pflügers Archiv : European journal of physiology·N S FregaA Leaf
May 1, 1986·Kidney International·P F ShanleyS Rosen
Nov 1, 1973·The American Journal of Physiology·B D RossA Leaf
Jan 1, 1972·The Journal of Clinical Investigation·J FloresA Leaf
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J I KreisbergA Leaf
Jul 1, 1982·Acta Physiologica Scandinavica·B Agerup, A E Persson

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Citations

Oct 1, 1991·Kidney International·S N HeymanS Rosen

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