Poly(ethylene glycol) monolayer formation and stability on gold and silicon nitride substrates

Langmuir : the ACS Journal of Surfaces and Colloids
Marta CerrutiRoya Maboudian

Abstract

Poly(ethylene glycol) (PEG) self-assembled monolayers (SAMs) are extensively used to modify substrates to prevent nonspecific protein adsorption and to increase hydrophilicity. X-ray photoelectron spectroscopy analysis, complemented by water contact angle measurements, is employed to investigate the formation and stability upon aging and heating of PEG monolayers formed on gold and silicon nitride substrates. In particular, thiolated PEG monolayers on gold, with and without the addition of an undecylic spacer chain, and PEG monolayers formed with oxysilane precursors on silicon nitride have been probed. It is found that PEG-thiol SAMs are degraded after less than two weeks of exposure to air and when heated at temperatures as low as 120 degrees C. On the contrary, PEG-silane SAMs are stable for more than two weeks, and fewer molecules are desorbed even after two months of aging, compared to those desorbed in two weeks from the PEG-thiol SAMs. A strongly bound hydration layer is found on PEG-silane SAMs aged for two months. Heating PEG-silane SAMs to temperatures as high as 160 degrees C improves the quality of the monolayer, desorbing weakly bound contaminants. The differences in stability between PEG-thiol SAMs and PEG-silane ...Continue Reading

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Citations

Dec 29, 2013·Journal of Colloid and Interface Science·Paola RivoloFrancesco Geobaldo
Sep 9, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Munehiro YamaguchiKazutoshi Gohara
Jun 10, 2010·Physical Chemistry Chemical Physics : PCCP·Stefan ZornFrank Schreiber
Oct 12, 2012·The Journal of Organic Chemistry·Rajesh KotaDaniell Lewis Mattern
Mar 27, 2015·Advanced Functional Materials·Diego PallarolaHorst Kessler
Jul 17, 2013·Colloids and Surfaces. B, Biointerfaces·Jiali CaoQilin Mei
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·E LlorensJ Puiggalí
May 22, 2016·Colloids and Surfaces. B, Biointerfaces·Chun-Jen HuangT Randall Lee
Jun 5, 2019·Sensors·Jessanne Y LichtenbergSeunghyun Kim
Oct 22, 2014·Physical Chemistry Chemical Physics : PCCP·Elena S KartashynskaReinhard Miller
Aug 14, 2020·Physical Chemistry Chemical Physics : PCCP·James B DerrValentine I Vullev
Oct 1, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Maria Felisa Z Lerum, Wei Chen
Jun 12, 2021·ACS Sensors·Mohamed A EttabibJames S Wilkinson
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sing Yee YeungBörje Sellergren
Feb 12, 2011·ACS Applied Materials & Interfaces·Michel RossoHan Zuilhof
Oct 3, 2019·ACS Applied Materials & Interfaces·Kenneth E MadsenAndrew A Gewirth

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