Polyethylene glycols (PEG) and related structures: overlooked allergens in the perioperative setting

A & a Case Reports
Emily WenandeLene H Garvey

Abstract

We describe hypersensitivity to polyethylene glycols (PEGs), with cross-reactivity to a structural analog, polysorbate 80, in a 69-year-old patient with perioperative anaphylaxis and subsequent, severe anaphylactic reactions to unrelated medical products. PEGs and PEG analogs are prevalent in the perioperative setting, contained in a wide range of products seldom suspected of causing hypersensitivity reactions and thus rarely documented in surgical/anesthetic records. We suggest routine testing for PEGs after perioperative anaphylaxis because exposure to these polymers often is significant. Comprehensive brand name documentation on the anesthetic chart of all product exposures is central to identifying the responsible allergen.

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Citations

May 20, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Wenande, L H Garvey
Apr 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·N Wagner, M Podda
Dec 9, 2015·Nucleic Acid Therapeutics·Mariya VorobyevaAlya Venyaminova
Sep 1, 2019·British Journal of Clinical Pharmacology·Cosby A StoneElizabeth J Phillips
Jan 5, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maria A Bruusgaard-MouritsenLene H Garvey
Apr 15, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Miguel AlpalhãoPaulo Filipe

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