Polyethyleneimine-functionalized platinum nanoparticles with high electrochemiluminescence activity and their applications to amplified analysis of biomolecules

Chemistry, an Asian Journal
Tao LiErkang Wang

Abstract

Polyethyleneimine-functionalized platinum nanoparticles (PtNPs) with excellent electrochemiluminescence (ECL) properties were synthesized and applied to the amplified analysis of biomolecules. These particles were prepared at room temperature, with hyperbranched polyethyleneimine (HBPEI) as the stabilizer. The UV/Vis absorption spectra and transmission electron microscopy images clearly confirmed the formation of monodisperse PtNPs. Such particles proved to possess high stability against salt-induced aggregation, enabling them to be employed even under high-salt conditions. Owing to the existence of many tertiary amine groups, these particles exhibited excellent ECL behavior in the presence of tris(2,2'-bipyridyl)ruthenium(II). An HBPEI-coated particle possessed an ECL activity that was at least 60 times higher than that of a tripropylamine molecule. Furthermore, these particles could be immobilized on the 3-aminopropyltriethoxysilane-treated quartz substrates to amplify the binding sites for carboxyl groups. Through this approach, PtNPs were applied to the amplified analysis of the hemin/G-quadruplex DNAzyme by using the luminol/H(2)O(2) chemiluminescence method.

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Citations

Mar 15, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Hui Wei, Erkang Wang
Feb 13, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Xin HuangYasushi Inouye
Dec 4, 2014·Analytica Chimica Acta·Jong-Min ParkJae-Chul Pyun
Mar 8, 2013·Bioorganic & Medicinal Chemistry Letters·Kazuhito TanabeSei-ichi Nishimoto
May 22, 2020·The Analyst·Rabbee G MahmudunnabiMuhammad J A Shiddiky
Mar 14, 2009·Chemical Communications : Chem Comm·Tao LiShaojun Dong

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