Polyethylenimine Modified and Non-Modified Polymeric Micelles Used for Nasal Administration of Carvedilol

Journal of Biomedical Nanotechnology
Emine KahramanYildiz Ozsoy

Abstract

This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (- 40.6)-(+ 25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol)5000 micelles, the polyethylenimine non-modified micelles, showed the highest perme...Continue Reading

Citations

Jul 20, 2016·The Journal of Pharmacy and Pharmacology·Marcel WegmannMarcela A Moretton
Jun 7, 2018·Anais Da Academia Brasileira De Ciências·Mariana Q MesquitaMaria Amparo F Faustino
Feb 8, 2019·Current Pharmaceutical Design·Mohini MishraAmit Modgil
Apr 21, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Meltem Ezgi DurgunYıldız Özsoy

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