Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012

Environmental Pollution
Robert L HerrickSusan M Pinney

Abstract

Industrial discharges of perfluorooctanoic acid (PFOA) to the Ohio River, contaminating water systems near Parkersburg, WV, were previously associated with nearby residents' serum PFOA concentrations above US general population medians. Ohio River PFOA concentrations downstream are elevated, suggesting Mid-Ohio River Valley residents are exposed through drinking water. Quantify PFOA and 10 other per- and polyfluoroalkyl substances (PFAS) in Mid-Ohio River Valley resident sera collected between 1991 and 2013 and determine whether the Ohio River and Ohio River Aquifer are exposure sources. We measured eleven PFAS in 1608 sera from 931 participants. Serum PFOA concentration and water source associations were assessed using linear mixed-effects models. We estimated between-sample serum PFOA using one-compartment pharmacokinetics for participants with multiple samples. In serum samples collected as early as 1991, PFOA (median = 7.6 ng/mL) was detected in 99.9% of sera; 47% had concentrations greater than US population 95th percentiles. Five other PFAS were detected in greater than 82% of samples; median other PFAS concentrations were similar to the US general population. Serum PFOA was significantly associated with water source, sam...Continue Reading

Associated Clinical Trials

Citations

Nov 30, 2019·Journal of Analytical Toxicology·M Abdul MottalebAndrew J Morris
Jul 11, 2020·International Journal of Phytoremediation·David K HuffKurt D Pennell
Dec 29, 2020·Ecotoxicology and Environmental Safety·Teresa Dalla ZuannaCristina Canova
Nov 18, 2020·Environmental Toxicology and Chemistry·Amila O De SilvaElsie M Sunderland
Jul 22, 2018·International Journal of Hygiene and Environmental Health·Courtney M GianniniSusan M Pinney
Jul 14, 2019·International Journal of Hygiene and Environmental Health·S M PinneyUNKNOWN Breast Cancer and the Environment Research Program

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