Polyfunctional T cell responses are a hallmark of HIV-2 infection.

European Journal of Immunology
Melody G DuvallR A Koup

Abstract

HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to investigate correlates of immune protection against HIV disease progression. Here, we report a detailed assessment of the HIV-2-specific CD4(+) and CD8(+) T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-gamma, IL-2, TNF-alpha, MIP-1beta, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation. We find that HIV-2-specific CD4(+) and CD8(+) T cells are more polyfunctional that those specific for HIV-1 and that polyfunctional HIV-2-specific T cells produce more IFN-gamma and TNF-alpha on a per-cell basis than monofunctional T cells. Polyfunctional HIV-2-specific CD4(+) T cells were generally more differentiated and expressed CD57, while there was no association between function and phenotype in the CD8(+) T cell fraction. Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in ...Continue Reading

References

Jan 1, 1985·Advances in Experimental Medicine and Biology·P HenkartC Reynolds
Jan 1, 1985·Annual Review of Immunology·P A Henkart
Sep 2, 1998·Current Opinion in Immunology·H C WhittleS Rowland-Jones
Dec 16, 2000·AIDS Research and Human Retroviruses·F ChamG van der Groen
May 3, 2002·Nature·Daniel C DouekRichard A Koup
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor AppayAnthony D Kelleher
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark J BoazAnnapurna Vyakarnam
Dec 19, 2002·AIDS Research and Human Retroviruses·Neil BerryHilton Whittle
Oct 7, 2003·Nature Medicine·Valerie RubioPeter P Lee
Oct 29, 2003·Journal of Immunological Methods·Michael R BettsRichard A Koup
Dec 17, 2003·The Journal of Experimental Medicine·Souheil-Antoine YounesRafick-Pierre Sekaly
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen C De RosaMario Roederer
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre HarariGiuseppe Pantaleo
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael R BettsGuido Ferrari
May 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Simone C ZimmerliGiuseppe Pantaleo
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melody G DuvallSarah L Rowland-Jones
Jun 8, 2006·Journal of Immunological Methods·Stephen P PerfettoMario Roederer
Jul 25, 2006·Nature Medicine·Pratip K ChattopadhyayMario Roederer
Dec 13, 2006·The Journal of Experimental Medicine·Joseph P CasazzaRichard A Koup
Mar 23, 2007·Journal of Virology·David J C MilesArnaud Marchant
May 31, 2007·The Journal of Experimental Medicine·Melissa L PrecopioRichard A Koup

❮ Previous
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Citations

Mar 5, 2009·Cancer Immunology, Immunotherapy : CII·Cedrik Michael BrittenUNKNOWN HLA-peptide Multimer Proficiency Panel of the CVC-CRI Immune Assay Working Group
Apr 6, 2011·Cancer Immunology, Immunotherapy : CII·Jianda YuanJedd D Wolchok
Aug 5, 2011·Archives of Virology·Salvatore DimonteMuhammed Babakir-Mina
Oct 8, 2008·Trends in Immunology·Igor M Belyakov, Jeffrey D Ahlers
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianda YuanJedd D Wolchok
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zaza M NdhlovuDiane E Griffin
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Natko NuberMaries van den Broek
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qing HanJ Christopher Love
May 4, 2012·The Journal of Infectious Diseases·Gabriel K PedersenRebecca J Cox
Oct 28, 2010·Current Opinion in HIV and AIDS·Hélène PerrinLydie Trautmann
Aug 10, 2010·The Cancer Journal·Cassian Yee
Apr 1, 2011·Transplantation·Karin MuellerNina Babel
Nov 11, 2011·Journal of Virology·Raskit LachmannFlorian Kern
Oct 25, 2008·Annual Review of Medicine·Daniel C DouekRichard A Koup
Mar 14, 2012·PloS One·Kjell EneslättAnders Sjöstedt
Apr 24, 2012·PloS One·Johannes NemethStefan Winkler
Jun 14, 2013·PloS One·Saghar KaabinejadianWilliam H Hildebrand
Dec 2, 2011·Journal of Vaccines & Vaccination·Daniela Santoro RosaEdecio Cunha-Neto
Feb 18, 2009·Cancer Immunology, Immunotherapy : CII·Jon Amund KyteGustav Gaudernack
Apr 25, 2009·Expert Opinion on Investigational Drugs·Jon Amund Kyte
Mar 19, 2013·Transplant Immunology·Yaneth M OrtizLuis F García

❮ Previous
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