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Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study

European Journal of Medicinal Chemistry

Sep 21, 2019

Yajun BaiXiaohui Zheng

Abstract

Inspired by the traditional Chinese herbal pair of Polygala tenuifolia-Acori Tatarinowii for treating epilepsy, 33 novel substituted cinnamic α-asaronol esters and analogues were designed by Combination of Traditional Chinese Medicine Molecular Chemistry (CTCMMC) strategy, synthesized a...read more

Mentioned in this Paper

Polygala tatarinowii
Noncompetitive Inhibition
Infantile Severe Myoclonic Epilepsy
Epilepsy
Carbamazepine
Protein kinase modulator
Drug Resistant Epilepsy
Pharmacologic Substance
Analogs & derivatives
Lactic acid dehydrogenase isoenzyme 5
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Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study

European Journal of Medicinal Chemistry

Sep 21, 2019

Yajun BaiXiaohui Zheng

PMID: 31539780

DOI: 10.1016/j.ejmech.2019.111650

Abstract

Inspired by the traditional Chinese herbal pair of Polygala tenuifolia-Acori Tatarinowii for treating epilepsy, 33 novel substituted cinnamic α-asaronol esters and analogues were designed by Combination of Traditional Chinese Medicine Molecular Chemistry (CTCMMC) strategy, synthesized a...read more

Mentioned in this Paper

Polygala tatarinowii
Noncompetitive Inhibition
Infantile Severe Myoclonic Epilepsy
Epilepsy
Carbamazepine
Protein kinase modulator
Drug Resistant Epilepsy
Pharmacologic Substance
Analogs & derivatives
Lactic acid dehydrogenase isoenzyme 5

Similar Papers Found In These Feeds

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