Polygenetic traits in pancreatic disorders

Endocrinology and Metabolism Clinics of North America
David C Whitcomb

Abstract

Rapid advances in information and technology provide opportunities to discover the risks or causes for various disorders within individual patients. The availability of new data and new technology has outstripped the conceptual framework of simple disorders,however, and challenges current statistical approaches. The author addresses the issues surrounding study design and sample size for complex genetic traits with special attention to meta-analysis and systems biology. The author concludes that meta-analysis should play a limited role in evaluating studies of complex genetic diseases. Instead, systems biology-based approaches should be developed to integrate multiple, focused, and mechanistic association studies, with the goal of assisting in the risk assessment of patients on a person-by-person basis.

References

Sep 3, 1998·The New England Journal of Medicine·N SharerJ Braganza
Sep 3, 1998·The New England Journal of Medicine·J A CohnP S Jowell
Jun 21, 2001·JAMA : the Journal of the American Medical Association·H WittV Keim
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Jan 19, 2002·Nature Genetics·Ingrid DahlmanPatrick Concannon
Jun 25, 2002·Best Practice & Research. Clinical Gastroenterology·Alexander Schneider, David C Whitcomb
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·L RossiD C Whitcomb
Feb 25, 2003·Lancet·John P A IoannidisDespina G Contopoulos-Ioannidis
May 3, 2003·Trends in Molecular Medicine·John P A Ioannidis
Mar 18, 2004·Journal of the National Cancer Institute·Sholom WacholderNathaniel Rothman
Jun 23, 2004·Journal of Clinical Psychopharmacology·John M Davis, Nancy Chen
Jun 24, 2004·European Journal of Human Genetics : EJHG·Thomas A TrikalinosJohn P A Ioannidis
Oct 30, 2004·Scandinavian Journal of Gastroenterology·A SchneiderD C Whitcomb
Jan 6, 2005·The American Journal of Pathology·Xiaoying DengDavid C Whitcomb
Mar 8, 2005·Drug Metabolism Reviews·Shufeng ZhouYu-Zong Chen
Sep 27, 2005·Lancet·Heather J Cordell, David G Clayton
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·David C Whitcomb
Jan 18, 2006·Digestive Diseases and Sciences·David C WhitcombM Michael Barmada

❮ Previous
Next ❯

Citations

May 20, 2014·La Revue de médecine interne·V Rebours

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.