Polygenic Basis and Variable Genetic Architectures Contribute to the Complex Nature of Body Weight -A Genome-Wide Study in Four Chinese Indigenous Chicken Breeds

Frontiers in Genetics
Yangyang YuanXiaoxiang Hu

Abstract

Body weight (BW) is one of the most important economic traits for animal production and breeding, and it has been studied extensively for its phenotype-genotype associations. While mapping studies have mostly aimed at finding as many loci as possible that contributed to the variation in BW, the role of other factors in its genetic architecture, including their frequencies in the population and their interactions, have been largely overlooked. To comprehensively characterized the genetic architecture of BW, we performed a genome-wide association study (GWAS) both at the single-marker and haplotype level on birds from four indigenous Chinese chicken breeds (Chahua, Silkie, Langshan, and Beard), rather than studying crosses between two founder lines. Additionally, samples from two more breeds (Red Junglefowl and Recessive White) were included to better reflect variable genetic characteristics across populations. Six loci were mapped in this study, revealing the polygenic basis underlying BW. Moreover, by further examining the frequencies of the significantly associated haplotypes in each subpopulation and their effect sizes, most of the loci were found to affect BW in the Beard chicken breed alone. Two loci in GGA9 and GGA27, howe...Continue Reading

References

Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 15, 2006·Nature Genetics·Orjan CarlborgLeif Andersson
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Jun 26, 2007·Bioinformatics·Peter J BradburyEdward S Buckler
May 14, 2009·Molecular Biology Reports·Meixia FangXiquan Zhang
Jun 2, 2011·BMC Genomics·Martien A M GroenenHans H Cheng
Jul 26, 2011·Database : the Journal of Biological Databases and Curation·Rhoda J KinsellaPaul Flicek
Mar 3, 2012·PloS One·Martin G ElferinkMartien A M Groenen
Apr 12, 2012·Journal of Lipid Research·Jingjing LiuGregory A Graf
Sep 10, 2014·Nature Reviews. Genetics·Wen-Hua WeiChris S Haley
Nov 19, 2014·Methods in Molecular Biology·Trudy F C Mackay
Nov 17, 2015·Genome Biology and Evolution·S QanbariH Simianer
Nov 26, 2015·Nucleic Acids Research·Zhi-Liang HuJames M Reecy
Jan 24, 2016·Plant Biotechnology Journal·Lunwen QianRod J Snowdon
Oct 17, 2016·Journal of Molecular Cell Biology·Ming-Shan WangYa-Ping Zhang
Dec 12, 2017·Nature Reviews. Genetics·Nicholas J TimpsonJ Brent Richards
Dec 16, 2017·Plant Science : an International Journal of Experimental Plant Biology·Ying-Hui LiLi-Juan Qiu

❮ Previous
Next ❯

Citations

Jan 23, 2020·Animals : an Open Access Journal From MDPI·Zengkui LuBohui Yang

❮ Previous
Next ❯

Software Mentioned

DAVID
ENSEMBL biomart
GenABEL
PLINK
fastPHASE
vGWAS
R package
Haploview
FarmCPU
R scripts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved