Polygenic Influence on Educational Attainment: New evidence from The National Longitudinal Study of Adolescent to Adult Health

AERA Open
Benjamin W DomingueJason D Boardman

Abstract

Recent studies have begun to uncover the genetic architecture of educational attainment. We build on this work using genome-wide data from siblings in the National Longitudinal Study of Adolescent to Adult Health (Add Health). We measure the genetic predisposition of siblings to educational attainment using polygenic scores. We then test how polygenic scores are related to social environments and educational outcomes. In Add Health, genetic predisposition to educational attainment is patterned across the social environment. Participants with higher polygenic scores were more likely to grow up in socially advantaged families. Even so, the previously published genetic associations appear to be causal. Among pairs of siblings, the sibling with the higher polygenic score typically went on to complete more years of schooling as compared to their lower-scored co-sibling. We found subtle differences between sibling fixed effect estimates of the genetic effect versus those based on unrelated individuals.

References

Jul 28, 2016·Scientific Reports·Dalton ConleyBenjamin W Domingue
Jul 18, 2017·Psychological Science·Ziada AyorechS von Stumm
Sep 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·George L WehbyFredric D Wolinsky
Dec 15, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·George L WehbyFredric D Wolinsky
Jan 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Benjamin W DomingueKathleen Mullan Harris
Aug 27, 2016·American Educational Research Journal·Katherine MagnusonMolly Metzger
Jul 21, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Michael A WoodleyDavide Piffer
Oct 21, 2016·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Michael A Woodley Of MenieKevin M Beaver
Sep 15, 2018·Cerebral Cortex·Maxwell L ElliottAhmad R Hariri
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dalton Conley, Ramina Sotoudeh
Jul 1, 2016·Sociological Science·Dalton Conley, Benjamin W Domingue
Jun 9, 2018·Nature Human Behaviour·Kaili RimfeldR Plomin
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Daniel W BelskyKathleen Mullan Harris
Jan 12, 2019·NPJ Science of Learning·H Moriah Sokolowski, Daniel Ansari
Feb 13, 2020·NPJ Science of Learning·K Paige HardenKathleen Mullan Harris
Jul 20, 2016·Molecular Psychiatry·S SelzamR Plomin
Aug 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ramina SotoudehDalton Conley
Aug 29, 2017·Journal of Health and Social Behavior·Elizabeth M Lawrence
Jun 27, 2020·Journal of the European Economic Association·Nicholas W Papageorge, Kevin Thom
Jul 2, 2019·International Journal of Epidemiology·Kathleen Mullan HarrisSarah C Dean
Mar 31, 2019·Nature Genetics·Alicia R MartinMark J Daly

Citations

May 11, 2001·Nature·David ReichE S Lander
Dec 21, 2002·Science·Noah A RosenbergMarcus Feldman
Feb 25, 2003·Lancet·Lon R Cardon, Lyle J Palmer
Nov 25, 2003·Psychological Science·Eric TurkheimerIrving I Gottesman
Apr 19, 2006·Nature Reviews. Genetics·Nan M Laird, Christoph Lange
Sep 6, 2007·Genome Research·Naomi R WrayPeter M Visscher
Feb 28, 2009·Journal of the History of Biology·James Tabery
May 9, 2009·PloS One·Mari NelisAndres Metspalu
Oct 28, 2009·Nature Reviews. Genetics·R PlominOliver S P Davis
Apr 28, 2010·Journal of Health and Social Behavior·Jason D BoardmanFred C Pampel
Jun 16, 2010·Nature Reviews. Genetics·Alkes L PriceNick Patterson
Aug 17, 2011·Demography·Jason D BoardmanLindon J Eaves
Jun 6, 2012·Archives of Pediatrics & Adolescent Medicine·Daniel W BelskyAvshalom Caspi
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jason D BoardmanJason M Fletcher
Dec 13, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kathleen Mullan HarrisAndrew Smolen
Apr 5, 2013·PLoS Genetics·Frank Dudbridge
May 25, 2013·Biodemography and Social Biology·Daniel W BelskyAvshalom Caspi
Aug 10, 2013·American Journal of Public Health·Daniel W BelskyAvshalom Caspi
Aug 10, 2013·American Journal of Public Health·Jason D BoardmanJeremy Freese
Dec 10, 2013·Nucleic Acids Research·Danielle WelterHelen Parkinson
Jan 17, 2014·The Lancet. Respiratory Medicine·Daniel W BelskyAvshalom Caspi
Jul 6, 2014·PloS One·Benjamin W DomingueJason D Boardman
Jul 22, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Eveline L de ZeeuwDorret I Boomsma
Oct 8, 2014·Psychological Science·Cornelius A RietveldSocial Science Genetics Association Consortium
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·E KrapohlR Plomin
Oct 25, 2014·Biodemography and Social Biology·Daniel W Belsky, Salomon Israel
Nov 8, 2014·Behavior Genetics·Matthew B McQueenKathleen Mullan Harris
Mar 31, 2015·Nature Neuroscience·Kimberly G NobleElizabeth R Sowell
Jan 1, 2015·Sociological Science·Dalton ConleyJason D Boardman

Related Concepts

Study
Genome
Longitudinal Studies
Environment
Participant
Polygene

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.