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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

bioRxiv

Sep 14, 2018

Tian GeJordan W. Smoller

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Abstract

Polygenic prediction has shown promise in identifying individuals at high risk for complex diseases, and may become clinically useful as the predictive performance of polygenic risk scores (PRS) improves. Here, we present PRS-CS, a novel polygenic prediction method that infers posterior...read more

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  • Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

    bioRxiv

    Sep 14, 2018

    Tian GeJordan W. Smoller

    DOI: 10.1101/416859

    Abstract

    Polygenic prediction has shown promise in identifying individuals at high risk for complex diseases, and may become clinically useful as the predictive performance of polygenic risk scores (PRS) improves. Here, we present PRS-CS, a novel polygenic prediction method that infers posterior...read more

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    22
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