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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

bioRxiv

Sep 14, 2018

Tian GeJordan W. Smoller

Abstract

Polygenic prediction has shown promise in identifying individuals at high risk for complex diseases, and may become clinically useful as the predictive performance of polygenic risk scores (PRS) improves. Here, we present PRS-CS, a novel polygenic prediction method that infers posterior...read more

Mentioned in this Paper

Biological Markers
Genome-Wide Association Study
Size
Patterns
2-Dimensional
Genome
Dysequilibrium Syndrome
Clearfil SE Bond
Genetic Markers
Genomics
46
22
Paper Details
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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

bioRxiv

Sep 14, 2018

Tian GeJordan W. Smoller

DOI: 10.1101/416859

Abstract

Polygenic prediction has shown promise in identifying individuals at high risk for complex diseases, and may become clinically useful as the predictive performance of polygenic risk scores (PRS) improves. Here, we present PRS-CS, a novel polygenic prediction method that infers posterior...read more

Mentioned in this Paper

Biological Markers
Genome-Wide Association Study
Size
Patterns
2-Dimensional
Genome
Dysequilibrium Syndrome
Clearfil SE Bond
Genetic Markers
Genomics
46
22

Similar Papers Found In These Feeds

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

Related Papers

bioRxiv

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioRxivMarch 2, 2015
Bjarni J VilhjálmssonAlkes L. Price
American Journal of Human Genetics

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

American Journal of Human GeneticsOctober 3, 2015
Bjarni J VilhjálmssonAlkes L. Price
Paper Details
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    References currently unavailable

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