Polygenic Risk, Appetite Traits, and Weight Gain in Middle Childhood: A Longitudinal Study

JAMA Pediatrics
Silje SteinsbekkLars Wichstrøm

Abstract

Genome-wide association studies have identified genetic risks for obesity. These genetic risks influence development of obesity partly by accelerating weight gain in childhood. Research is needed to identify mechanisms to inform intervention. Cross-sectional studies suggest appetite traits as a candidate mechanism. Longitudinal studies are needed to test whether appetite traits mediate genetic influences on children's weight gain. To test whether genetic risk for obesity predicts accelerated weight gain in middle childhood (ages 4-8 years) and whether genetic association with accelerated weight gain is mediated by appetite traits. Longitudinal study of a representative birth cohort at the Trondheim Early Secure Study, Trondheim, Norway, enrolled at age 4 years during 2007 to 2008, with follow-ups at ages 6 and 8 years. Participants were sampled from all children born in 2003 or 2004 who attended regular community health checkups for 4-year-olds (97.2% attendance; 82.0% consent rate, n = 2475). Nine hundred ninety-five children participated at age 4 years, 795 at age 6 years, and 699 at age 8 years. Analyses included 652 children with genotype, adiposity, and appetite data. Outcomes were body mass index and body-fat phenotypes m...Continue Reading

Citations

Jun 18, 2017·Circulation. Cardiovascular Genetics·Fatemeh SeyednasrollahOlli T Raitakari
Feb 1, 2019·Pediatric Obesity·Blandine de Lauzon-GuillainUNKNOWN EDEN Mother-Child Cohort Study Group
Feb 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Catherine G Russell, Alan Russell
Sep 15, 2019·Current Diabetes Reports·Ayo P DoumateyCharles N Rotimi
Dec 8, 2017·Diabetes·Mingyang SongEdward L Giovannucci
May 15, 2021·Sleep Medicine·Victoria GarfieldSilje Steinsbekk
Jan 13, 2021·Nature Human Behaviour·Moritz HerleNadia Micali
Sep 4, 2020·Current Obesity Reports·Moritz HerleClare Llewellyn
Nov 5, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Guiomar MasipUNKNOWN IDEFICS/I.Family Consortia

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