Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study

Journal of Studies on Alcohol and Drugs
James J LiDanielle M Dick

Abstract

Alcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality. We used a genome-wide approach to examine associations between genetic risk for alcohol use problems, personality dimensions, and adolescent alcohol use problems in two separate longitudinal population-based samples, the Finnish Twin Cohort (FinnTwin12) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants were 1,035 young adults from FinnTwin12 and 3,160 adolescents from ALSPAC. Polygenic risk scores (PRS) were calculated for ALSPAC using genome-wide association results (on alcohol dependence symptoms as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) from FinnTwin12. A parallel multiple mediator model was tested to examine whether the association between PRS and alcohol use problems assessed at age 16 could be explained by variations in personality dimensions assessed at...Continue Reading

Citations

Feb 23, 2018·Nature Reviews. Neuroscience·Linda P Spear
Jun 9, 2018·Journal of Translational Medicine·Yosr HamdiUNKNOWN PEC Consortium
Aug 3, 2019·Alcoholism, Clinical and Experimental Research·Albert J KsinanDanielle M Dick
Dec 12, 2017·Genes, Brain, and Behavior·Danielle M DickJinni Su
Jul 22, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jinni SuDanielle M Dick
Oct 24, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Richard J RoseJaakko Kaprio
Jan 17, 2021·International Journal of Environmental Research and Public Health·Chisato HayashiKazuo Hayakawa
Mar 6, 2021·Translational Psychiatry·Mira TschornUNKNOWN IMAGEN Consortium
Apr 27, 2021·Eating and Weight Disorders : EWD·Leon HirveläAnna Keski-Rahkonen
Dec 21, 2021·Development and Psychopathology·Sarah A HartmannElisa M Trucco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.